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1zgy
From Proteopedia
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| - | [[Image:1zgy.png|left|200px]] | ||
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{{STRUCTURE_1zgy| PDB=1zgy | SCENE= }} | {{STRUCTURE_1zgy| PDB=1zgy | SCENE= }} | ||
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===Structural and Biochemical Basis for Selective Repression of the Orphan Nuclear Receptor LRH-1 by SHP=== | ===Structural and Biochemical Basis for Selective Repression of the Orphan Nuclear Receptor LRH-1 by SHP=== | ||
| + | {{ABSTRACT_PUBMED_15976031}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/NR0B2_RAT NR0B2_RAT]] Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:015976031</ref><references group="xtra"/> | + | <ref group="xtra">PMID:015976031</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
Revision as of 22:58, 24 March 2013
Contents |
Structural and Biochemical Basis for Selective Repression of the Orphan Nuclear Receptor LRH-1 by SHP
Template:ABSTRACT PUBMED 15976031
Function
[NR0B2_RAT] Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.
About this Structure
1zgy is a 2 chain structure with sequence from Homo sapiens and Rattus norvegicus. Full crystallographic information is available from OCA.
See Also
Reference
- Li Y, Choi M, Suino K, Kovach A, Daugherty J, Kliewer SA, Xu HE. Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner. Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9505-10. Epub 2005 Jun 23. PMID:15976031
