1hw8

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[[Image:1hw8.png|left|200px]]
 
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{{STRUCTURE_1hw8| PDB=1hw8 | SCENE= }}
{{STRUCTURE_1hw8| PDB=1hw8 | SCENE= }}
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===COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH COMPACTIN (ALSO KNOWN AS MEVASTATIN)===
===COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH COMPACTIN (ALSO KNOWN AS MEVASTATIN)===
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{{ABSTRACT_PUBMED_11349148}}
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{{ABSTRACT_PUBMED_11349148}}
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==Function==
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[[http://www.uniprot.org/uniprot/HMDH_HUMAN HMDH_HUMAN]] Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
==About this Structure==
==About this Structure==
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[[1hw8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HW8 OCA].
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[[1hw8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HW8 OCA].
==See Also==
==See Also==
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==Reference==
==Reference==
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<ref group="xtra">PMID:011349148</ref><references group="xtra"/>
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<ref group="xtra">PMID:011349148</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Deisenhofer, J.]]
[[Category: Deisenhofer, J.]]
[[Category: Istvan, E S.]]
[[Category: Istvan, E S.]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]

Revision as of 14:12, 12 March 2014

Template:STRUCTURE 1hw8

Contents

COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH COMPACTIN (ALSO KNOWN AS MEVASTATIN)

Template:ABSTRACT PUBMED 11349148

Function

[HMDH_HUMAN] Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

About this Structure

1hw8 is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA.

See Also

Reference

  • Istvan ES, Deisenhofer J. Structural mechanism for statin inhibition of HMG-CoA reductase. Science. 2001 May 11;292(5519):1160-4. PMID:11349148 doi:10.1126/science.1059344

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