3s9e
From Proteopedia
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{{STRUCTURE_3s9e| PDB=3s9e | SCENE= }} | {{STRUCTURE_3s9e| PDB=3s9e | SCENE= }} | ||
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===Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-glutamate=== | ===Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-glutamate=== | ||
| + | {{ABSTRACT_PUBMED_21907808}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/GRIK3_RAT GRIK3_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.<ref>PMID:21907808</ref> | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021907808</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021907808</ref><references group="xtra"/><references/> |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Frydenvang, K.]] | [[Category: Frydenvang, K.]] | ||
Revision as of 06:14, 2 October 2013
Contents |
Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-glutamate
Template:ABSTRACT PUBMED 21907808
Function
[GRIK3_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.[1]
About this Structure
3s9e is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
See Also
Reference
- Venskutonyte R, Frydenvang K, Gajhede M, Bunch L, Pickering DS, Kastrup JS. Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. J Struct Biol. 2011 Sep 1. PMID:21907808 doi:10.1016/j.jsb.2011.08.014
- ↑ Venskutonyte R, Frydenvang K, Gajhede M, Bunch L, Pickering DS, Kastrup JS. Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. J Struct Biol. 2011 Sep 1. PMID:21907808 doi:10.1016/j.jsb.2011.08.014
