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1nwx

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[[Image:1nwx.gif|left|200px]]<br /><applet load="1nwx" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1nwx.gif|left|200px]]
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caption="1nwx, resolution 3.50&Aring;" />
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'''COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH ABT-773'''<br />
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{{Structure
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|PDB= 1nwx |SIZE=350|CAPTION= <scene name='initialview01'>1nwx</scene>, resolution 3.50&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=773:CETHROMYCIN'>773</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH ABT-773'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1NWX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] with <scene name='pdbligand=773:'>773</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWX OCA].
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1NWX is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWX OCA].
==Reference==
==Reference==
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Structural basis for the antibiotic activity of ketolides and azalides., Schlunzen F, Harms JM, Franceschi F, Hansen HA, Bartels H, Zarivach R, Yonath A, Structure. 2003 Mar;11(3):329-38. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12623020 12623020]
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Structural basis for the antibiotic activity of ketolides and azalides., Schlunzen F, Harms JM, Franceschi F, Hansen HA, Bartels H, Zarivach R, Yonath A, Structure. 2003 Mar;11(3):329-38. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12623020 12623020]
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Zarivach, R.]]
[[Category: Zarivach, R.]]
[[Category: 773]]
[[Category: 773]]
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[[Category: 50s]]
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[[Category: 50]]
[[Category: abt-773]]
[[Category: abt-773]]
[[Category: ketolide]]
[[Category: ketolide]]
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[[Category: ribosome]]
[[Category: ribosome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:11:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:02:45 2008''

Revision as of 11:02, 20 March 2008

Image:1nwx.gif


PDB ID 1nwx

Drag the structure with the mouse to rotate
, resolution 3.50Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH ABT-773


Overview

The azalide azithromycin and the ketolide ABT-773, which were derived by chemical modifications of erythromycin, exhibit elevated activity against a number of penicillin- and macrolide-resistant pathogenic bacteria. Analysis of the crystal structures of the large ribosomal subunit from Deinococcus radiodurans complexed with azithromycin or ABT-773 indicates that, despite differences in the number and nature of their contacts with the ribosome, both compounds exert their antimicrobial activity by blocking the protein exit tunnel. In contrast to all macrolides studied so far, two molecules of azithromycin bind simultaneously to the tunnel. The additional molecule also interacts with two proteins, L4 and L22, implicated in macrolide resistance. These studies illuminated and rationalized the enhanced activity of the drugs against specific macrolide-resistant bacteria.

About this Structure

1NWX is a Protein complex structure of sequences from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

Structural basis for the antibiotic activity of ketolides and azalides., Schlunzen F, Harms JM, Franceschi F, Hansen HA, Bartels H, Zarivach R, Yonath A, Structure. 2003 Mar;11(3):329-38. PMID:12623020

Page seeded by OCA on Thu Mar 20 13:02:45 2008

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