1nzg
From Proteopedia
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| - | [[Image:1nzg.gif|left|200px]] | + | [[Image:1nzg.gif|left|200px]] |
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| - | '''Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine''' | + | {{Structure |
| + | |PDB= 1nzg |SIZE=350|CAPTION= <scene name='initialview01'>1nzg</scene>, resolution 1.60Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1NZG is a [ | + | 1NZG is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZG OCA]. |
==Reference== | ==Reference== | ||
| - | 2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects., Prhavc M, Prakash TP, Minasov G, Cook PD, Egli M, Manoharan M, Org Lett. 2003 Jun 12;5(12):2017-20. PMID:[http:// | + | 2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects., Prhavc M, Prakash TP, Minasov G, Cook PD, Egli M, Manoharan M, Org Lett. 2003 Jun 12;5(12):2017-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12790517 12790517] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Egli, M.]] | [[Category: Egli, M.]] | ||
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[[Category: Prakash, T P.]] | [[Category: Prakash, T P.]] | ||
[[Category: Prhavc, M.]] | [[Category: Prhavc, M.]] | ||
| - | [[Category: 2'-modified | + | [[Category: 2'-modified oligonucleotide]] |
[[Category: a-dna]] | [[Category: a-dna]] | ||
[[Category: crystal structure]] | [[Category: crystal structure]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:03:43 2008'' |
Revision as of 11:03, 20 March 2008
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| , resolution 1.60Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine
Overview
[structure: see text] Oligonucleotides with a novel, 2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] (2'-O-DMAEOE) modification have been synthesized. This modification, a cationic analogue of the 2'-O-(2-methoxyethyl) (2'-O-MOE) modification, exhibits high binding affinity to target RNA (but not to DNA) and exceptional resistance to nuclease degradation. Analysis of the crystal structure of a self-complementary oligonucleotide containing a single 2'-O-DMAEOE modification explains the importance of charge factors and gauche effects on the observed antisense properties. 2'-O-DMAEOE modified oligonucleotides are ideal candidates for antisense drugs.
About this Structure
1NZG is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects., Prhavc M, Prakash TP, Minasov G, Cook PD, Egli M, Manoharan M, Org Lett. 2003 Jun 12;5(12):2017-20. PMID:12790517
Page seeded by OCA on Thu Mar 20 13:03:43 2008
