3nf5
From Proteopedia
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| - | [[ | + | ==Crystal structure of the C-terminal domain of nuclear pore complex component NUP116 from Candida glabrata== |
| + | <StructureSection load='3nf5' size='340' side='right' caption='[[3nf5]], [[Resolution|resolution]] 1.94Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3nf5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NF5 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CAGL0F06171g, NUP116 (gi50287617) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5478 Candida glabrata])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nf5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nf5 RCSB], [http://www.ebi.ac.uk/pdbsum/3nf5 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nf/3nf5_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The nuclear pore complex (NPC), embedded in the nuclear envelope, is a large, dynamic molecular assembly that facilitates exchange of macromolecules between the nucleus and the cytoplasm. The yeast NPC is an eightfold symmetric annular structure composed of ~456 polypeptide chains contributed by ~30 distinct proteins termed nucleoporins. Nup116, identified only in fungi, plays a central role in both protein import and mRNA export through the NPC. Nup116 is a modular protein with N-terminal "FG" repeats containing a Gle2p-binding sequence motif and a NPC targeting domain at its C-terminus. We report the crystal structure of the NPC targeting domain of Candida glabrata Nup116, consisting of residues 882-1034 [CgNup116(882-1034)], at 1.94 A resolution. The X-ray structure of CgNup116(882-1034) is consistent with the molecular envelope determined in solution by small-angle X-ray scattering. Structural similarities of CgNup116(882-1034) with homologous domains from Saccharomyces cerevisiae Nup116, S. cerevisiae Nup145N, and human Nup98 are discussed. | ||
| - | + | Atomic structure of the nuclear pore complex targeting domain of a Nup116 homologue from the yeast, Candida glabrata.,Sampathkumar P, Kim SJ, Manglicmot D, Bain KT, Gilmore J, Gheyi T, Phillips J, Pieper U, Fernandez-Martinez J, Franke JD, Matsui T, Tsuruta H, Atwell S, Thompson DA, Emtage JS, Wasserman SR, Rout MP, Sali A, Sauder JM, Almo SC, Burley SK Proteins. 2012 Aug;80(8):2110-6. doi: 10.1002/prot.24102. Epub 2012 Jun 4. PMID:22544723<ref>PMID:22544723</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Nucleoporin|Nucleoporin]] | *[[Nucleoporin|Nucleoporin]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Candida glabrata]] | [[Category: Candida glabrata]] | ||
| - | [[Category: Atwell, S | + | [[Category: Atwell, S]] |
| - | [[Category: Bain, K | + | [[Category: Bain, K]] |
| - | [[Category: Burley, S K | + | [[Category: Burley, S K]] |
| - | [[Category: Emtage, J S | + | [[Category: Emtage, J S]] |
| - | [[Category: Gheyi, T | + | [[Category: Gheyi, T]] |
| - | [[Category: Gilmore, J | + | [[Category: Gilmore, J]] |
| - | [[Category: Manglicmot, D | + | [[Category: Manglicmot, D]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Rout, M | + | [[Category: Rout, M]] |
| - | [[Category: Sali, A | + | [[Category: Sali, A]] |
| - | [[Category: Sampathkumar, P | + | [[Category: Sampathkumar, P]] |
| - | [[Category: Sauder, J M | + | [[Category: Sauder, J M]] |
| - | [[Category: Thompson, D A | + | [[Category: Thompson, D A]] |
| - | [[Category: Wasserman, S | + | [[Category: Wasserman, S]] |
[[Category: Glebs domain]] | [[Category: Glebs domain]] | ||
| - | [[Category: New | + | [[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]] |
| - | + | ||
[[Category: Nuclear pore complex]] | [[Category: Nuclear pore complex]] | ||
[[Category: Nup116]] | [[Category: Nup116]] | ||
| - | [[Category: | + | [[Category: PSI, Protein structure initiative]] |
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[[Category: Protein transport]] | [[Category: Protein transport]] | ||
| - | [[Category: Psi-2]] | ||
| - | [[Category: Structural genomic]] | ||
Revision as of 13:28, 6 November 2014
Crystal structure of the C-terminal domain of nuclear pore complex component NUP116 from Candida glabrata
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Categories: Candida glabrata | Atwell, S | Bain, K | Burley, S K | Emtage, J S | Gheyi, T | Gilmore, J | Manglicmot, D | Structural genomic | Rout, M | Sali, A | Sampathkumar, P | Sauder, J M | Thompson, D A | Wasserman, S | Glebs domain | NYSGXRC, New York SGX Research Center for Structural Genomics | Nuclear pore complex | Nup116 | PSI, Protein structure initiative | Protein transport
