3quy
From Proteopedia
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| - | [[ | + | ==Structure of the mouse CD1d-BnNH-GSL-1'-iNKT TCR complex== |
| + | <StructureSection load='3quy' size='340' side='right' caption='[[3quy]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3quy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QUY FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=QUY:(2S,3R,4S,5R,6S)-6-[(2S,3S,4R)-2-(HEXACOSANOYLAMINO)-3,4-DIHYDROXY-OCTADECOXY]-3,4,5-TRIHYDROXY-N-(PHENYLMETHYL)OXANE-2-CARBOXAMIDE'>QUY</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qux|3qux]], [[3quz|3quz]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cd1.1, CD1d, Cd1d1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2m, beta-2-microglobulin, mCG_11606, RP23-34E24.5-001 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3quy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3quy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3quy RCSB], [http://www.ebi.ac.uk/pdbsum/3quy PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Invariant natural killer T (iNKT) cells are known to have marked immunomodulatory capacity due to their ability to produce copious amounts of effector cytokines. Here, we report the structure and function of a novel class of aromatic alpha-galactosylceramide structurally related glycolipids with marked Th1 bias in both mice and men, leading to superior tumour protection in vivo. The strength of the Th1 response correlates well with enhanced lipid binding to CD1d as a result of an induced fit mechanism that binds the aromatic substitution as a third anchor, in addition to the two lipid chains. This induced fit is in contrast to another Th1-biasing glycolipid, alpha-C-GalCer, whose CD1d binding follows a conventional key-lock principle. These findings highlight the previously unexploited flexibility of CD1d in accommodating galactose-modified glycolipids and broaden the range of glycolipids that can stimulate iNKT cells. We speculate that glycolipids can be designed that induce a similar fit, thereby leading to superior and more sustained iNKT cell responses in vivo. | ||
| - | + | Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis.,Aspeslagh S, Li Y, Yu ED, Pauwels N, Trappeniers M, Girardi E, Decruy T, Van Beneden K, Venken K, Drennan M, Leybaert L, Wang J, Franck RW, Van Calenbergh S, Zajonc DM, Elewaut D EMBO J. 2011 Jun 1;30(11):2294-305. Epub 2011 May 6. PMID:21552205<ref>PMID:21552205</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Beta-2 microglobulin|Beta-2 microglobulin]] | *[[Beta-2 microglobulin|Beta-2 microglobulin]] | ||
| - | + | *[[CD1|CD1]] | |
| - | == | + | == References == |
| - | < | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Girardi, E | + | [[Category: Girardi, E]] |
| - | [[Category: Li, Y | + | [[Category: Li, Y]] |
| - | [[Category: Yu, E D | + | [[Category: Yu, E D]] |
| - | [[Category: Zajonc, D M | + | [[Category: Zajonc, D M]] |
[[Category: Antigen presentation]] | [[Category: Antigen presentation]] | ||
[[Category: Glycolipid]] | [[Category: Glycolipid]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Nkt cell]] | [[Category: Nkt cell]] | ||
Revision as of 13:06, 9 December 2014
Structure of the mouse CD1d-BnNH-GSL-1'-iNKT TCR complex
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