3j10

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[[Image:3j10.png|left|200px]]
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==Structural characterization of mRNA-tRNA translocation intermediates (30S ribosome of class 6 of the six classes)==
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<StructureSection load='3j10' size='340' side='right' caption='[[3j10]], [[Resolution|resolution]] 11.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3j10]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J10 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J10 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2MG:2N-METHYLGUANOSINE-5-MONOPHOSPHATE'>2MG</scene>, <scene name='pdbligand=4OC:4N,O2-METHYLCYTIDINE-5-MONOPHOSPHATE'>4OC</scene>, <scene name='pdbligand=4SU:4-THIOURIDINE-5-MONOPHOSPHATE'>4SU</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=5MU:5-METHYLURIDINE+5-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=7MG:7N-METHYL-8-HYDROGUANOSINE-5-MONOPHOSPHATE'>7MG</scene>, <scene name='pdbligand=H2U:5,6-DIHYDROURIDINE-5-MONOPHOSPHATE'>H2U</scene>, <scene name='pdbligand=MA6:6N-DIMETHYLADENOSINE-5-MONOPHOSHATE'>MA6</scene>, <scene name='pdbligand=MIA:2-METHYLTHIO-N6-ISOPENTENYL-ADENOSINE-5-MONOPHOSPHATE'>MIA</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=UR3:3-METHYLURIDINE-5-MONOPHOSHATE'>UR3</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2i2u|2i2u]], [[2i2v|2i2v]], [[3j0u|3j0u]], [[3j0t|3j0t]], [[3j13|3j13]], [[3j11|3j11]], [[3j0v|3j0v]], [[3j0w|3j0w]], [[3j0x|3j0x]], [[3j0y|3j0y]], [[3j0z|3j0z]], [[3j12|3j12]], [[3j14|3j14]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j10 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j10 RCSB], [http://www.ebi.ac.uk/pdbsum/3j10 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cryo-EM analysis of a wild-type Escherichia coli pretranslocational sample has revealed the presence of previously unseen intermediate substates of the bacterial ribosome during the first phase of translocation, characterized by intermediate intersubunit rotations, L1 stalk positions, and tRNA configurations. Furthermore, we describe the domain rearrangements in quantitative terms, which has allowed us to characterize the processivity and coordination of the conformational reorganization of the ribosome, along with the associated changes in tRNA ribosome-binding configuration. The results are consistent with the view of the ribosome as a molecular machine employing Brownian motion to reach a functionally productive state via a series of substates with incremental changes in conformation.
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{{STRUCTURE_3j10| PDB=3j10 | SCENE= }}
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Structural characterization of mRNA-tRNA translocation intermediates.,Agirrezabala X, Liao HY, Schreiner E, Fu J, Ortiz-Meoz RF, Schulten K, Green R, Frank J Proc Natl Acad Sci U S A. 2012 Mar 30. PMID:22467828<ref>PMID:22467828</ref>
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===Structural characterization of mRNA-tRNA translocation intermediates (30S ribosome of class 6 of the six classes)===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_22467828}}
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==About this Structure==
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[[3j10]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J10 OCA].
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==See Also==
==See Also==
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*[[Ribosomal protein S10|Ribosomal protein S10]]
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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*[[Ribosomal protein S11|Ribosomal protein S11]]
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== References ==
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*[[Ribosomal protein S12|Ribosomal protein S12]]
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<references/>
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*[[Ribosomal protein S13|Ribosomal protein S13]]
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__TOC__
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*[[Ribosomal protein S14|Ribosomal protein S14]]
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</StructureSection>
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*[[Ribosomal protein S15|Ribosomal protein S15]]
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*[[Ribosomal protein S16|Ribosomal protein S16]]
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*[[Ribosomal protein S17|Ribosomal protein S17]]
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*[[Ribosomal protein S18|Ribosomal protein S18]]
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*[[Ribosomal protein S19|Ribosomal protein S19]]
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*[[Ribosomal protein S20|Ribosomal protein S20]]
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*[[Ribosomal protein S21|Ribosomal protein S21]]
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*[[Ribosomal protein S3|Ribosomal protein S3]]
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*[[Ribosomal protein S4|Ribosomal protein S4]]
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*[[Ribosomal protein S5|Ribosomal protein S5]]
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*[[Ribosomal protein S6|Ribosomal protein S6]]
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*[[Ribosomal protein S7|Ribosomal protein S7]]
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*[[Ribosomal protein S8|Ribosomal protein S8]]
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*[[Ribosomal protein S9|Ribosomal protein S9]]
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==Reference==
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<ref group="xtra">PMID:022467828</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Agirrezabala, X.]]
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[[Category: Agirrezabala, X]]
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[[Category: Frank, J.]]
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[[Category: Frank, J]]
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[[Category: Fu, J.]]
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[[Category: Fu, J]]
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[[Category: Green, R.]]
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[[Category: Green, R]]
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[[Category: Liao, H.]]
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[[Category: Liao, H]]
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[[Category: Ortiz-Meoz, R F.]]
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[[Category: Ortiz-Meoz, R F]]
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[[Category: Schreiner, E.]]
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[[Category: Schreiner, E]]
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[[Category: Schulten, K.]]
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[[Category: Schulten, K]]
[[Category: Cryoelectron microscopy]]
[[Category: Cryoelectron microscopy]]
[[Category: Molecular dynamics flexible fitting]]
[[Category: Molecular dynamics flexible fitting]]
[[Category: Ratchet-like rotation]]
[[Category: Ratchet-like rotation]]
[[Category: Ribosome]]
[[Category: Ribosome]]

Revision as of 08:38, 8 December 2014

Structural characterization of mRNA-tRNA translocation intermediates (30S ribosome of class 6 of the six classes)

3j10, resolution 11.50Å

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