2per

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[[Image:2per.png|left|200px]]
 
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{{STRUCTURE_2per| PDB=2per | SCENE= }}
{{STRUCTURE_2per| PDB=2per | SCENE= }}
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===Crystal Structure of Human Chloride Intracellular Channel protein 2===
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===Crystal Structure of Human Chloride Intracellular Channel protein 2===
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==Disease==
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[[http://www.uniprot.org/uniprot/CLIC2_HUMAN CLIC2_HUMAN]] Note=Defects in CLIC2 are a cause of a mental retardation with cardiopathy and seizures. Cardiac features include atrial fibrillation, cardiomegaly, and congestive heart failure.
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==Function==
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[[http://www.uniprot.org/uniprot/CLIC2_HUMAN CLIC2_HUMAN]] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.<ref>PMID:15147738</ref><ref>PMID:15916532</ref><ref>PMID:17945253</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:018186468</ref><references group="xtra"/>
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<ref group="xtra">PMID:018186468</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Liang, Y H.]]
[[Category: Liang, Y H.]]

Revision as of 03:18, 25 March 2013

Template:STRUCTURE 2per

Contents

Crystal Structure of Human Chloride Intracellular Channel protein 2

Disease

[CLIC2_HUMAN] Note=Defects in CLIC2 are a cause of a mental retardation with cardiopathy and seizures. Cardiac features include atrial fibrillation, cardiomegaly, and congestive heart failure.

Function

[CLIC2_HUMAN] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.[1][2][3]

About this Structure

2per is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Mi W, Liang YH, Li L, Su XD. The crystal structure of human chloride intracellular channel protein 2: a disulfide bond with functional implications. Proteins. 2008 Apr;71(1):509-13. PMID:18186468 doi:10.1002/prot.21922
  1. ↑ Board PG, Coggan M, Watson S, Gage PW, Dulhunty AF. CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels. Int J Biochem Cell Biol. 2004 Aug;36(8):1599-612. PMID:15147738 doi:10.1016/j.biocel.2004.01.026
  2. ↑ Dulhunty AF, Pouliquin P, Coggan M, Gage PW, Board PG. A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP. Biochem J. 2005 Aug 15;390(Pt 1):333-43. PMID:15916532 doi:BJ20042113
  3. ↑ Cromer BA, Gorman MA, Hansen G, Adams JJ, Coggan M, Littler DR, Brown LJ, Mazzanti M, Breit SN, Curmi PM, Dulhunty AF, Board PG, Parker MW. Structure of the Janus protein human CLIC2. J Mol Biol. 2007 Nov 30;374(3):719-31. Epub 2007 Sep 20. PMID:17945253 doi:http://dx.doi.org/10.1016/j.jmb.2007.09.041

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