1g5m

From Proteopedia

Revision as of 05:14, 25 March 2013

spinqualitylabelsall models PDB ID 1g5m Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1g5m, 1 NMR models ()
Related:	1bxl, 1g5j, 1g5o
Structural annotation: Resources: CATH : 1G5Ma00 InterPro : Ipr004725, Ipr013278, Ipr003093, Ipr000712, Ipr002475, Ipr012238 Pfam : PF00452 SCOP : d1g5ma_ UniProt : P10415
Functional annotation: Cellular component: mitochondrial outer membrane membrane cytoplasm nucleus endoplasmic reticulum nuclear membrane mitochondrion cytosol integral to membrane Biological process: response to nicotine regulation of mitochondrial membrane potential pigmentation anti-apoptosis negative regulation of mitochondrial depolarization response to radiation regulation of mitochondrial membrane permeability regulation of protein homodimerization activity response to iron ion response to toxin female pregnancy regulation of protein heterodimerization activity hair follicle morphogenesis apoptosis positive regulation of cell proliferation regulation of apoptosis humoral immune response defense response to virus negative regulation of neuron apoptosis negative regulation of cellular pH reduction release of cytochrome c from mitochondria negative regulation of apoptosis neuron apoptosis regulation of viral genome replication Molecular function: protein heterodimerization activity identical protein binding protein binding protease binding protein homodimerization activity BH3 domain binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

HUMAN BCL-2, ISOFORM 1

Template:ABSTRACT PUBMED 11248023

Disease

[BCL2_HUMAN] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.

Function

[BCL2_HUMAN] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).^[1]

About this Structure

1g5m is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

See Also

• Bcl-2
• Horseradish peroxidase

Reference

• Petros AM, Medek A, Nettesheim DG, Kim DH, Yoon HS, Swift K, Matayoshi ED, Oltersdorf T, Fesik SW. Solution structure of the antiapoptotic protein bcl-2. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3012-7. Epub 2001 Feb 27. PMID:11248023 doi:10.1073/pnas.041619798

1. ↑ Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell. 2008 Jun 20;30(6):678-88. doi: 10.1016/j.molcel.2008.06.001. PMID:18570871 doi:10.1016/j.molcel.2008.06.001