1ybv
From Proteopedia
(New page: 200px<br /> <applet load="1ybv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ybv, resolution 2.8Å" /> '''STRUCTURE OF TRIHYDR...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1YBV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Magnaporthe_grisea Magnaporthe grisea]] with NDP and BEA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.50 1.3.1.50]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1YBV OCA]]. | + | 1YBV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Magnaporthe_grisea Magnaporthe grisea]] with NDP and BEA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.50 1.3.1.50]]. Structure known Active Sites: A1, A2, B1 and B2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1YBV OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:32:35 2007'' |
Revision as of 06:27, 30 October 2007
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STRUCTURE OF TRIHYDROXYNAPHTHALENE REDUCTASE IN COMPLEX WITH NADPH AND AN ACTIVE SITE INHIBITOR
Overview
BACKGROUND: The enzyme 1,3,8-trihydroxynaphthalene reductase (THNR), catalyzes an essential reaction in the biosynthesis of melanin, a black, pigment crucial for the pathogenesis of the rice blast fungus, Magnaporthe, grisea. The enzyme is the biochemical target of several commercially, important fungicides which are used to prevent blast disease in rice, plants. We have determined the structure of the ternary complex of THNR, with bound NADPH and a fungicide, tricyclazole. RESULTS: Crystallographic, analysis showed four identical subunits of THNR to form a tetramer with, 222 symmetry. The enzyme subunit consists of a single domain comprising a, seven-stranded beta sheet flanked by eight alpha helices; the subunit, contains a dinucleotide-binding fold which binds the coenzyme, NADPH., ... [(full description)]
About this Structure
1YBV is a [Single protein] structure of sequence from [Magnaporthe grisea] with NDP and BEA as [ligands]. Active as [Oxidoreductase], with EC number [1.3.1.50]. Structure known Active Sites: A1, A2, B1 and B2. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the ternary complex of 1,3,8-trihydroxynaphthalene reductase from Magnaporthe grisea with NADPH and an active-site inhibitor., Andersson A, Jordan D, Schneider G, Lindqvist Y, Structure. 1996 Oct 15;4(10):1161-70. PMID:8939741
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