2kkg
From Proteopedia
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{{STRUCTURE_2kkg| PDB=2kkg | SCENE= }} | {{STRUCTURE_2kkg| PDB=2kkg | SCENE= }} | ||
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===NMR structure of the octarepeat region of prion protein bound to pentosan polysulfate=== | ===NMR structure of the octarepeat region of prion protein bound to pentosan polysulfate=== | ||
| + | {{ABSTRACT_PUBMED_19913031}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc. | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).<ref>PMID:19059915</ref> | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:019913031</ref><references group="xtra"/> | + | <ref group="xtra">PMID:019913031</ref><references group="xtra"/><references/> |
[[Category: Mesocricetus auratus]] | [[Category: Mesocricetus auratus]] | ||
[[Category: Caughey, B.]] | [[Category: Caughey, B.]] | ||
Revision as of 06:46, 25 March 2013
Contents |
NMR structure of the octarepeat region of prion protein bound to pentosan polysulfate
Template:ABSTRACT PUBMED 19913031
Disease
[PRIO_MESAU] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
Function
[PRIO_MESAU] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).[1]
About this Structure
2kkg is a 1 chain structure with sequence from Mesocricetus auratus. Full experimental information is available from OCA.
See Also
Reference
- Taubner LM, Bienkiewicz EA, Copie V, Caughey B. Structure of the flexible amino-terminal domain of prion protein bound to a sulfated glycan. J Mol Biol. 2010 Jan 22;395(3):475-90. Epub 2009 Nov 10. PMID:19913031 doi:10.1016/j.jmb.2009.10.075
- ↑ Juanes ME, Elvira G, Garcia-Grande A, Calero M, Gasset M. Biosynthesis of prion protein nucleocytoplasmic isoforms by alternative initiation of translation. J Biol Chem. 2009 Jan 30;284(5):2787-94. doi: 10.1074/jbc.M804051200. Epub 2008, Dec 5. PMID:19059915 doi:10.1074/jbc.M804051200
