3l21
From Proteopedia
(Difference between revisions)
m (Protected "3l21" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | + | ==The crystal structure of a dimeric mutant of dihydrodipicolinate synthase (DAPA, RV2753C) from Mycobacterium Tuberculosis - DHDPS-A204R== | |
| - | + | <StructureSection load='3l21' size='340' side='right' caption='[[3l21]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3l21]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L21 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=KPI:(2S)-2-AMINO-6-[(1-HYDROXY-1-OXO-PROPAN-2-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xxx|1xxx]], [[2ojp|2ojp]]</td></tr> | |
| - | == | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dapA, MT2823, MTV002.18c, Rv2753c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr> |
| - | [[3l21]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L21 OCA]. | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrodipicolinate_synthase Dihydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.52 4.2.1.52] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l21 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l21 RCSB], [http://www.ebi.ac.uk/pdbsum/3l21 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DAPA_MYCTU DAPA_MYCTU]] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA) (Probable).<ref>PMID:18062777</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Dihydrodipicolinate | + | *[[Dihydrodipicolinate synthase|Dihydrodipicolinate synthase]] |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Dihydrodipicolinate synthase]] | [[Category: Dihydrodipicolinate synthase]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
| - | [[Category: Devenish, S R | + | [[Category: Devenish, S R]] |
| - | [[Category: Evans, G L | + | [[Category: Evans, G L]] |
| - | [[Category: Gerrard, J A | + | [[Category: Gerrard, J A]] |
| - | [[Category: Jamerson, G B | + | [[Category: Jamerson, G B]] |
| - | [[Category: Schuldt, L | + | [[Category: Schuldt, L]] |
| - | [[Category: Weiss, M S | + | [[Category: Weiss, M S]] |
[[Category: Amino-acid biosynthesis]] | [[Category: Amino-acid biosynthesis]] | ||
[[Category: Dapa]] | [[Category: Dapa]] | ||
[[Category: Dhdp]] | [[Category: Dhdp]] | ||
[[Category: Diaminopimelate biosynthesis]] | [[Category: Diaminopimelate biosynthesis]] | ||
| - | [[Category: Dihydrodipicolinate synthase]] | ||
[[Category: Dimer]] | [[Category: Dimer]] | ||
[[Category: Lyase]] | [[Category: Lyase]] | ||
[[Category: Lysine biosynthesis]] | [[Category: Lysine biosynthesis]] | ||
| - | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Rv2753c]] | [[Category: Rv2753c]] | ||
[[Category: Schiff base]] | [[Category: Schiff base]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 22:37, 25 December 2014
The crystal structure of a dimeric mutant of dihydrodipicolinate synthase (DAPA, RV2753C) from Mycobacterium Tuberculosis - DHDPS-A204R
| |||||||||||
Categories: Dihydrodipicolinate synthase | Mycobacterium tuberculosis | Devenish, S R | Evans, G L | Gerrard, J A | Jamerson, G B | Schuldt, L | Weiss, M S | Amino-acid biosynthesis | Dapa | Dhdp | Diaminopimelate biosynthesis | Dimer | Lyase | Lysine biosynthesis | Rv2753c | Schiff base | Transferase
