1o7x
From Proteopedia
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| - | [[Image:1o7x.jpg|left|200px]] | + | [[Image:1o7x.jpg|left|200px]] |
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| - | '''CITRATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS''' | + | {{Structure |
| + | |PDB= 1o7x |SIZE=350|CAPTION= <scene name='initialview01'>1o7x</scene>, resolution 2.7Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Citrate_(Si)-synthase Citrate (Si)-synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.1 2.3.3.1] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''CITRATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1O7X is a [ | + | 1O7X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7X OCA]. |
==Reference== | ==Reference== | ||
| - | Stepwise adaptations of citrate synthase to survival at life's extremes. From psychrophile to hyperthermophile., Bell GS, Russell RJ, Connaris H, Hough DW, Danson MJ, Taylor GL, Eur J Biochem. 2002 Dec;269(24):6250-60. PMID:[http:// | + | Stepwise adaptations of citrate synthase to survival at life's extremes. From psychrophile to hyperthermophile., Bell GS, Russell RJ, Connaris H, Hough DW, Danson MJ, Taylor GL, Eur J Biochem. 2002 Dec;269(24):6250-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12473121 12473121] |
[[Category: Citrate (Si)-synthase]] | [[Category: Citrate (Si)-synthase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: tricarboxylic acid cycle]] | [[Category: tricarboxylic acid cycle]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:06:59 2008'' |
Revision as of 11:07, 20 March 2008
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| , resolution 2.7Å | |||||||
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| Activity: | Citrate (Si)-synthase, with EC number 2.3.3.1 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CITRATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS
Overview
The crystal structure of citrate synthase from the thermophilic Archaeon Sulfolobus solfataricus (optimum growth temperature = 85 degrees C) has been determined, extending the number of crystal structures of citrate synthase from different organisms to a total of five that span the temperature range over which life exists (from psychrophile to hyperthermophile). Detailed structural analysis has revealed possible molecular mechanisms that determine the different stabilities of the five proteins. The key to these mechanisms is the precise structural location of the additional interactions. As one ascends the temperature ladder, the subunit interface of this dimeric enzyme and loop regions are reinforced by complex electrostatic interactions, and there is a reduced exposure of hydrophobic surface. These observations reveal a progressive pattern of stabilization through multiple additional interactions at solvent exposed, loop and interfacial regions.
About this Structure
1O7X is a Single protein structure of sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.
Reference
Stepwise adaptations of citrate synthase to survival at life's extremes. From psychrophile to hyperthermophile., Bell GS, Russell RJ, Connaris H, Hough DW, Danson MJ, Taylor GL, Eur J Biochem. 2002 Dec;269(24):6250-60. PMID:12473121
Page seeded by OCA on Thu Mar 20 13:06:59 2008
