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1wkn

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{{Theoretical_model}}
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==A PLAUSIBLE MODEL OF FULL-LENGTH INTEGRASEDNA COMPLEX==
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<StructureSection load='1wkn' size='340' side='right' caption='[[1wkn]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WKN FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wkn FirstGlance], [http://www.ebi.ac.uk/pdbsum/1wkn PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A model of the full-length HIV-1 integrase dimer was constructed assembling the experimentally determined structures of the single domains. Subsequently, the three-domain protein-viral DNA complex was generated for the first time through an automated docking algorithm, obtained modifying the ESCHER program, a well-known method for protein-protein docking. A detailed study of the contacts established with DNA by the enzyme revealed that the predicted model reproduced the results of mutagenesis and cross-linking experiments, confirming the validity of our docking approach in predicting the base specificity in the DNA-protein interaction.
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[[Image:1wkn.png|left|200px]]
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Analysis of the full-length integrase-DNA complex by a modified approach for DNA docking.,De Luca L, Pedretti A, Vistoli G, Barreca ML, Villa L, Monforte P, Chimirri A Biochem Biophys Res Commun. 2003 Oct 31;310(4):1083-8. PMID:14559226<ref>PMID:14559226</ref>
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{{STRUCTURE_1wkn| PDB=1wkn | SCENE= }}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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===A PLAUSIBLE MODEL OF FULL-LENGTH INTEGRASEDNA COMPLEX===
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14559226}}
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:014559226</ref><references group="xtra"/>
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[[Category: Barreca, M L]]
[[Category: Barreca, M L]]
[[Category: Chimirri, A]]
[[Category: Chimirri, A]]

Revision as of 22:11, 28 September 2014

A PLAUSIBLE MODEL OF FULL-LENGTH INTEGRASEDNA COMPLEX

1wkn

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