1ocr

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[[Image:1ocr.gif|left|200px]]<br /><applet load="1ocr" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ocr.gif|left|200px]]
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caption="1ocr, resolution 2.35&Aring;" />
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'''BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE'''<br />
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{{Structure
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|PDB= 1ocr |SIZE=350|CAPTION= <scene name='initialview01'>1ocr</scene>, resolution 2.35&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=HEA:HEME-A'>HEA</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Cytochrome-c_oxidase Cytochrome-c oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.9.3.1 1.9.3.1]
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|GENE=
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}}
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'''BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1OCR is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=CU:'>CU</scene>, <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=HEA:'>HEA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cytochrome-c_oxidase Cytochrome-c oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.9.3.1 1.9.3.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OCR OCA].
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1OCR is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OCR OCA].
==Reference==
==Reference==
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Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase., Yoshikawa S, Shinzawa-Itoh K, Nakashima R, Yaono R, Yamashita E, Inoue N, Yao M, Fei MJ, Libeu CP, Mizushima T, Yamaguchi H, Tomizaki T, Tsukihara T, Science. 1998 Jun 12;280(5370):1723-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9624044 9624044]
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Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase., Yoshikawa S, Shinzawa-Itoh K, Nakashima R, Yaono R, Yamashita E, Inoue N, Yao M, Fei MJ, Libeu CP, Mizushima T, Yamaguchi H, Tomizaki T, Tsukihara T, Science. 1998 Jun 12;280(5370):1723-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9624044 9624044]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Cytochrome-c oxidase]]
[[Category: Cytochrome-c oxidase]]
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[[Category: reduced]]
[[Category: reduced]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:16:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:09:05 2008''

Revision as of 11:09, 20 March 2008

Image:1ocr.gif


PDB ID 1ocr

Drag the structure with the mouse to rotate
, resolution 2.35Å
Ligands: , , , and
Activity: Cytochrome-c oxidase, with EC number 1.9.3.1
Coordinates: save as pdb, mmCIF, xml



BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE


Overview

Crystal structures of bovine heart cytochrome c oxidase in the fully oxidized, fully reduced, azide-bound, and carbon monoxide-bound states were determined at 2.30, 2.35, 2.9, and 2.8 angstrom resolution, respectively. An aspartate residue apart from the O2 reduction site exchanges its effective accessibility to the matrix aqueous phase for one to the cytosolic phase concomitantly with a significant decrease in the pK of its carboxyl group, on reduction of the metal sites. The movement indicates the aspartate as the proton pumping site. A tyrosine acidified by a covalently linked imidazole nitrogen is a possible proton donor for the O2 reduction by the enzyme.

About this Structure

1OCR is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase., Yoshikawa S, Shinzawa-Itoh K, Nakashima R, Yaono R, Yamashita E, Inoue N, Yao M, Fei MJ, Libeu CP, Mizushima T, Yamaguchi H, Tomizaki T, Tsukihara T, Science. 1998 Jun 12;280(5370):1723-9. PMID:9624044

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