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1od1
From Proteopedia
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| - | [[Image:1od1.jpg|left|200px]] | + | [[Image:1od1.jpg|left|200px]] |
| - | + | ||
| - | '''ENDOTHIAPEPSIN PD135,040 COMPLEX''' | + | {{Structure |
| + | |PDB= 1od1 |SIZE=350|CAPTION= <scene name='initialview01'>1od1</scene>, resolution 1.37Å | ||
| + | |SITE= <scene name='pdbsite=CAT:Catalytic+Aspartates'>CAT</scene> | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''ENDOTHIAPEPSIN PD135,040 COMPLEX''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1OD1 is a [ | + | 1OD1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD1 OCA]. |
==Reference== | ==Reference== | ||
| - | The structure of endothiapepsin complexed with the gem-diol inhibitor PD-135,040 at 1.37 A., Coates L, Erskine PT, Mall S, Williams PA, Gill RS, Wood SP, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):978-81. Epub 2003, May 23. PMID:[http:// | + | The structure of endothiapepsin complexed with the gem-diol inhibitor PD-135,040 at 1.37 A., Coates L, Erskine PT, Mall S, Williams PA, Gill RS, Wood SP, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):978-81. Epub 2003, May 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12777758 12777758] |
[[Category: Cryphonectria parasitica]] | [[Category: Cryphonectria parasitica]] | ||
[[Category: Endothiapepsin]] | [[Category: Endothiapepsin]] | ||
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[[Category: inhibitor]] | [[Category: inhibitor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:09:07 2008'' |
Revision as of 11:09, 20 March 2008
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| , resolution 1.37Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | |||||||
| Activity: | Endothiapepsin, with EC number 3.4.23.22 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
ENDOTHIAPEPSIN PD135,040 COMPLEX
Overview
The crystal structure of endothiapepsin complexed with the gem-diol inhibitor PD-135,040 has been anisotropically refined to a resolution of 1.37 A. The structure of this inhibitor complex is in agreement with previous structures of endothiapepsin gem-diol inhibitor complexes that have been used to develop proposed catalytic mechanisms. However, the increase in resolution over previous structures confirms the presence of a number of short hydrogen bonds within the active site that are likely to play an important role in the catalytic mechanism. The presence of low-barrier hydrogen bonds was indicated in a previous one-dimensional H NMR spectrum.
About this Structure
1OD1 is a Protein complex structure of sequences from Cryphonectria parasitica. Full crystallographic information is available from OCA.
Reference
The structure of endothiapepsin complexed with the gem-diol inhibitor PD-135,040 at 1.37 A., Coates L, Erskine PT, Mall S, Williams PA, Gill RS, Wood SP, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):978-81. Epub 2003, May 23. PMID:12777758
Page seeded by OCA on Thu Mar 20 13:09:07 2008
