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2psk

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{{Theoretical_model}}
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==THEORETICAL MODEL OF AN FAB FRAGMENT COMPLEXED WITH THE MELANOMA-ASSOCIATED GD2 GANGLIOSIDE==
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<StructureSection load='2psk' size='340' side='right' caption='[[2psk]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PSK FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2psk FirstGlance], [http://www.ebi.ac.uk/pdbsum/2psk PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The GD2 ganglioside is a cell-surface component that appears on the surface of metastatic melanoma cells and is a marker for the progression of the disease. The ME36.1 monoclonal antibody binds to the GD2 ganglioside and has shown potential as a therapeutic antibody. ME36.1 is a possible alternative therapy to radiation, which is often ineffective in late-stage melanoma. The crystal structure of the Fab fragment of ME36.1 has been determined using molecular replacement and refined to an R factor of 20.4% at 2.8 A resolution. The model has good geometry with root-mean-square deviations of 0.008 A from ideal bond lengths and 1.7 degrees from ideal bond angles. The crystal structure of the ME36.1 Fab shows that its complementarity determining region forms a groove-shaped binding site rather than the pocket-type observed in other sugar binding Fabs. Molecular modeling has placed a four-residue sugar, representative of GD2, in the antigen binding site. The GD2 sugar moiety is stabilized by a network of hydrogen bonds that define the specificity of ME36.1 toward its antigen.
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[[Image:2psk.png|left|200px]]
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The crystal structure of a Fab fragment to the melanoma-associated GD2 ganglioside.,Pichla SL, Murali R, Burnett RM J Struct Biol. 1997 Jun;119(1):6-16. PMID:9216084<ref>PMID:9216084</ref>
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{{STRUCTURE_2psk| PDB=2psk | SCENE= }}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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===THEORETICAL MODEL OF AN FAB FRAGMENT COMPLEXED WITH THE MELANOMA-ASSOCIATED GD2 GANGLIOSIDE===
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9216084}}
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:009216084</ref><references group="xtra"/>
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[[Category: Burnett, R M]]
[[Category: Burnett, R M]]
[[Category: Murali, R]]
[[Category: Murali, R]]
[[Category: Pichla, S L]]
[[Category: Pichla, S L]]

Revision as of 01:05, 2 October 2014

THEORETICAL MODEL OF AN FAB FRAGMENT COMPLEXED WITH THE MELANOMA-ASSOCIATED GD2 GANGLIOSIDE

2psk

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