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1oeb

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[[Image:1oeb.gif|left|200px]]<br /><applet load="1oeb" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1oeb.gif|left|200px]]
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caption="1oeb, resolution 1.76&Aring;" />
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'''MONA/GADS SH3C DOMAIN'''<br />
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{{Structure
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|PDB= 1oeb |SIZE=350|CAPTION= <scene name='initialview01'>1oeb</scene>, resolution 1.76&Aring;
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|SITE= <scene name='pdbsite=CD1:Cd+Binding+Site+For+Chain+A'>CD1</scene>
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|LIGAND= <scene name='pdbligand=CD:CADMIUM ION'>CD</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''MONA/GADS SH3C DOMAIN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1OEB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=CD:'>CD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=CD1:Cd+Binding+Site+For+Chain+A'>CD1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEB OCA].
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1OEB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEB OCA].
==Reference==
==Reference==
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Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76., Harkiolaki M, Lewitzky M, Gilbert RJ, Jones EY, Bourette RP, Mouchiroud G, Sondermann H, Moarefi I, Feller SM, EMBO J. 2003 Jun 2;22(11):2571-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12773374 12773374]
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Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76., Harkiolaki M, Lewitzky M, Gilbert RJ, Jones EY, Bourette RP, Mouchiroud G, Sondermann H, Moarefi I, Feller SM, EMBO J. 2003 Jun 2;22(11):2571-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12773374 12773374]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: CD]]
[[Category: CD]]
[[Category: dimer]]
[[Category: dimer]]
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[[Category: gads]]
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[[Category: gad]]
[[Category: mona]]
[[Category: mona]]
[[Category: sh3]]
[[Category: sh3]]
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[[Category: slp-76]]
[[Category: slp-76]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:16:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:09:38 2008''

Revision as of 11:09, 20 March 2008

Image:1oeb.gif


PDB ID 1oeb

Drag the structure with the mouse to rotate
, resolution 1.76Å
Sites:
Ligands:
Coordinates: save as pdb, mmCIF, xml



MONA/GADS SH3C DOMAIN


Overview

SH3 domains are protein recognition modules within many adaptors and enzymes. With more than 500 SH3 domains in the human genome, binding selectivity is a key issue in understanding the molecular basis of SH3 domain interactions. The Grb2-like adaptor protein Mona/Gads associates stably with the T-cell receptor signal transducer SLP-76. The crystal structure of a complex between the C-terminal SH3 domain (SH3C) of Mona/Gads and a SLP-76 peptide has now been solved to 1.7 A. The peptide lacks the canonical SH3 domain binding motif P-x-x-P and does not form a frequently observed poly-proline type II helix. Instead, it adopts a clamp-like shape around the circumfence of the SH3C beta-barrel. The central R-x-x-K motif of the peptide forms a 3(10) helix and inserts into a negatively charged double pocket on the SH3C while several other residues complement binding through hydrophobic interactions, creating a short linear SH3C binding epitope of uniquely high affinity. Interestingly, the SH3C displays ion-dependent dimerization in the crystal and in solution, suggesting a novel mechanism for the regulation of SH3 domain functions.

About this Structure

1OEB is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76., Harkiolaki M, Lewitzky M, Gilbert RJ, Jones EY, Bourette RP, Mouchiroud G, Sondermann H, Moarefi I, Feller SM, EMBO J. 2003 Jun 2;22(11):2571-82. PMID:12773374

Page seeded by OCA on Thu Mar 20 13:09:38 2008

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