1oek

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[[Image:1oek.jpg|left|200px]]<br /><applet load="1oek" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1oek.jpg|left|200px]]
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caption="1oek, resolution 2.4&Aring;" />
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'''YODA FROM ESCHERICHIA COLI CRYSTALLISED WITH ZINC IONS'''<br />
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{{Structure
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|PDB= 1oek |SIZE=350|CAPTION= <scene name='initialview01'>1oek</scene>, resolution 2.4&Aring;
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>
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|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''YODA FROM ESCHERICHIA COLI CRYSTALLISED WITH ZINC IONS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1OEK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEK OCA].
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1OEK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEK OCA].
==Reference==
==Reference==
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YodA from Escherichia coli is a metal-binding, lipocalin-like protein., David G, Blondeau K, Schiltz M, Penel S, Lewit-Bentley A, J Biol Chem. 2003 Oct 31;278(44):43728-35. Epub 2003 Aug 8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12909634 12909634]
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YodA from Escherichia coli is a metal-binding, lipocalin-like protein., David G, Blondeau K, Schiltz M, Penel S, Lewit-Bentley A, J Biol Chem. 2003 Oct 31;278(44):43728-35. Epub 2003 Aug 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12909634 12909634]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: yoda]]
[[Category: yoda]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:16:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:09:47 2008''

Revision as of 11:09, 20 March 2008

Image:1oek.jpg


PDB ID 1oek

Drag the structure with the mouse to rotate
, resolution 2.4Å
Sites:
Ligands:
Coordinates: save as pdb, mmCIF, xml



YODA FROM ESCHERICHIA COLI CRYSTALLISED WITH ZINC IONS


Overview

We have determined the crystal structure of YodA, an Escherichia coli protein of unknown function. YodA had been identified under conditions of cadmium stress, and we confirm that it binds metals such as cadmium and zinc. We have also found nickel bound in one of the crystal forms. YodA is composed of two domains: a main lipocalin/calycin-like domain and a helical domain. The principal metal-binding site lies on one side of the calycin domain, thus making YodA the first metal-binding lipocalin known. Our experiments suggest that YodA expression may be part of a more general stress response. From sequence analogy with the C-terminal domain of a metal-binding receptor of a member of bacterial ATP-binding cassette transporters, we propose a three-dimensional model for this receptor and suggest that YodA may have a receptor-type partner in E. coli.

About this Structure

1OEK is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

YodA from Escherichia coli is a metal-binding, lipocalin-like protein., David G, Blondeau K, Schiltz M, Penel S, Lewit-Bentley A, J Biol Chem. 2003 Oct 31;278(44):43728-35. Epub 2003 Aug 8. PMID:12909634

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