2a4i

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{{Theoretical_model}}
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==HOMOLOGY MODEL OF VIMELYSIN==
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<StructureSection load='2a4i' size='340' side='right' caption='[[2a4i]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A4I FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4i FirstGlance], [http://www.ebi.ac.uk/pdbsum/2a4i PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Vimelysin is a metalloproteinase with high activity at low temperature and an unusual resistance to organic solvents. Substrate specificities of vimelysin and thermolysin were examined using FRETS-libraries, revealing a significant difference at the P3' position: vimelysin preferred acidic amino acid residues, whereas thermolysin preferred basic residues. Homology modeling of vimelysin suggests that oppositely charged residues in the S3' subsites (R215 in vimelysin and D213 in thermolysin) may be responsible for this specificity difference. This hypothesis was confirmed by examining the R215D mutant of vimelysin, which showed a substrate specificity profile intermediate between thermolysin and vimelysin.
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[[Image:2a4i.png|left|200px]]
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Exploring the subsite-structure of vimelysin and thermolysin using FRETS-libraries.,Oda K, Takahashi T, Takada K, Tsunemi M, Ng KK, Hiraga K, Harada S FEBS Lett. 2005 Sep 12;579(22):5013-8. PMID:16139276<ref>PMID:16139276</ref>
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{{STRUCTURE_2a4i| PDB=2a4i | SCENE= }}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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===HOMOLOGY MODEL OF VIMELYSIN===
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16139276}}
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:016139276</ref><references group="xtra"/>
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[[Category: Harada, S]]
[[Category: Harada, S]]
[[Category: Hiraga, K]]
[[Category: Hiraga, K]]

Revision as of 05:10, 29 September 2014

HOMOLOGY MODEL OF VIMELYSIN

2a4i

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