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1okx

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[[Image:1okx.gif|left|200px]]<br /><applet load="1okx" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1okx.gif|left|200px]]
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caption="1okx, resolution 2.80&Aring;" />
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'''BINDING STRUCTURE OF ELASTASE INHIBITOR SCYPTOLIN A'''<br />
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{{Structure
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|PDB= 1okx |SIZE=350|CAPTION= <scene name='initialview01'>1okx</scene>, resolution 2.80&Aring;
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|SITE= <scene name='pdbsite=SC1:Scyptolin+A+Binding+Site+For+Chain+B'>SC1</scene>
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|LIGAND=
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|ACTIVITY= [http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36]
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|GENE=
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}}
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'''BINDING STRUCTURE OF ELASTASE INHIBITOR SCYPTOLIN A'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1OKX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Scytonema_hofmanni Scytonema hofmanni] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Active as [http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] Known structural/functional Site: <scene name='pdbsite=SC1:Scyptolin+A+Binding+Site+For+Chain+B'>SC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OKX OCA].
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1OKX is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Scytonema_hofmanni Scytonema hofmanni] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OKX OCA].
==Reference==
==Reference==
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Binding structure of elastase inhibitor scyptolin A., Matern U, Schleberger C, Jelakovic S, Weckesser J, Schulz GE, Chem Biol. 2003 Oct;10(10):997-1001. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14583266 14583266]
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Binding structure of elastase inhibitor scyptolin A., Matern U, Schleberger C, Jelakovic S, Weckesser J, Schulz GE, Chem Biol. 2003 Oct;10(10):997-1001. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14583266 14583266]
[[Category: Pancreatic elastase]]
[[Category: Pancreatic elastase]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: protease]]
[[Category: protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:18:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:12:16 2008''

Revision as of 11:12, 20 March 2008

Image:1okx.gif


PDB ID 1okx

Drag the structure with the mouse to rotate
, resolution 2.80Å
Sites:
Activity: Pancreatic elastase, with EC number 3.4.21.36
Coordinates: save as pdb, mmCIF, xml



BINDING STRUCTURE OF ELASTASE INHIBITOR SCYPTOLIN A


Overview

Natural bioactive compounds are of general interest to pharmaceutical research because they may be used as leads in drug development campaigns. Among them, scyptolin A and B from Scytonema hofmanni PCC 7110 are known to inhibit porcine pancreatic elastase, which in turn resembles the attractive drug target neutrophil elastase. The crystal structure of scyptolin A as bound to pancreatic elastase was solved at 2.8 A resolution. The inhibitor occupies the most prominent subsites S1 through S4 of the elastase and prevents a hydrolytic attack by covering the active center with its rigid ring structure. The observed binding structure may help to design potent elastase inhibitors.

About this Structure

1OKX is a Protein complex structure of sequences from Scytonema hofmanni and Sus scrofa. Full crystallographic information is available from OCA.

Reference

Binding structure of elastase inhibitor scyptolin A., Matern U, Schleberger C, Jelakovic S, Weckesser J, Schulz GE, Chem Biol. 2003 Oct;10(10):997-1001. PMID:14583266

Page seeded by OCA on Thu Mar 20 13:12:16 2008

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