1b98

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m (Protected "1b98" [edit=sysop:move=sysop])
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[[Image:1b98.png|left|200px]]
 
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{{STRUCTURE_1b98| PDB=1b98 | SCENE= }}
{{STRUCTURE_1b98| PDB=1b98 | SCENE= }}
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===NEUROTROPHIN 4 (HOMODIMER)===
===NEUROTROPHIN 4 (HOMODIMER)===
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{{ABSTRACT_PUBMED_10631974}}
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{{ABSTRACT_PUBMED_10631974}}
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==Disease==
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[[http://www.uniprot.org/uniprot/NTF4_HUMAN NTF4_HUMAN]] Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O) [MIM:[http://omim.org/entry/613100 613100]]. A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
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==Function==
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[[http://www.uniprot.org/uniprot/NTF4_HUMAN NTF4_HUMAN]] Target-derived survival factor for peripheral sensory sympathetic neurons.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:010631974</ref><references group="xtra"/>
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<ref group="xtra">PMID:010631974</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Neurotrophins]]
[[Category: Neurotrophins]]

Revision as of 09:48, 24 March 2013

Template:STRUCTURE 1b98

Contents

NEUROTROPHIN 4 (HOMODIMER)

Template:ABSTRACT PUBMED 10631974

Disease

[NTF4_HUMAN] Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O) [MIM:613100]. A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.

Function

[NTF4_HUMAN] Target-derived survival factor for peripheral sensory sympathetic neurons.

About this Structure

1b98 is a 2 chain structure with sequence from Homo sapiens. The August 2005 RCSB PDB Molecule of the Month feature on Neurotrophins by David S. Goodsell is 10.2210/rcsb_pdb/mom_2005_8. Full crystallographic information is available from OCA.

Reference

  • Robinson RC, Radziejewski C, Spraggon G, Greenwald J, Kostura MR, Burtnick LD, Stuart DI, Choe S, Jones EY. The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site. Protein Sci. 1999 Dec;8(12):2589-97. PMID:10631974

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OCA

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