1otc
From Proteopedia
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| - | [[Image:1otc.gif|left|200px]] | + | [[Image:1otc.gif|left|200px]] |
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| - | '''THE O. NOVA TELOMERE END BINDING PROTEIN COMPLEXED WITH SINGLE STRAND DNA''' | + | {{Structure |
| + | |PDB= 1otc |SIZE=350|CAPTION= <scene name='initialview01'>1otc</scene>, resolution 2.80Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= MAC-56A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=200597 Sterkiella nova]), MAC-41A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=200597 Sterkiella nova]) | ||
| + | }} | ||
| + | |||
| + | '''THE O. NOVA TELOMERE END BINDING PROTEIN COMPLEXED WITH SINGLE STRAND DNA''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1OTC is a [ | + | 1OTC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Sterkiella_nova Sterkiella nova]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OTC OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA., Horvath MP, Schweiker VL, Bevilacqua JM, Ruggles JA, Schultz SC, Cell. 1998 Dec 23;95(7):963-74. PMID:[http:// | + | Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA., Horvath MP, Schweiker VL, Bevilacqua JM, Ruggles JA, Schultz SC, Cell. 1998 Dec 23;95(7):963-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9875850 9875850] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Sterkiella nova]] | [[Category: Sterkiella nova]] | ||
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[[Category: ob fold]] | [[Category: ob fold]] | ||
[[Category: oligonucleotide and oligosaccharide binding fold]] | [[Category: oligonucleotide and oligosaccharide binding fold]] | ||
| - | [[Category: protein dna | + | [[Category: protein dna interaction]] |
| - | [[Category: protein protein | + | [[Category: protein protein interaction]] |
[[Category: single strand dna binding protein]] | [[Category: single strand dna binding protein]] | ||
| - | [[Category: | + | [[Category: telomere]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:15:19 2008'' |
Revision as of 11:15, 20 March 2008
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| , resolution 2.80Å | |||||||
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| Gene: | MAC-56A (Sterkiella nova), MAC-41A (Sterkiella nova) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE O. NOVA TELOMERE END BINDING PROTEIN COMPLEXED WITH SINGLE STRAND DNA
Overview
Telomeres are specialized protein-DNA complexes that compose the ends of eukaryotic chromosomes. Telomeres protect chromosome termini from degradation and recombination and act together with telomerase to ensure complete genome replication. We have determined the crystal structure of the two-subunit Oxytricha nova telomere end binding protein (OnTEBP) complexed with single strand telomeric DNA at 2.8 A resolution. The structure reveals four oligonucleotide/oligosaccharide-binding folds, three of which form a deep cleft that binds the ssDNA, and a fourth that forms an unusual protein-protein interaction between the alpha and beta subunits. This structure provides a molecular description of how the two subunits of OnTEBP recognize and bind ssDNA to form a sequence-specific, telomeric nucleoprotein complex that caps the very 3' ends of chromosomes.
About this Structure
1OTC is a Protein complex structure of sequences from Sterkiella nova. Full crystallographic information is available from OCA.
Reference
Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA., Horvath MP, Schweiker VL, Bevilacqua JM, Ruggles JA, Schultz SC, Cell. 1998 Dec 23;95(7):963-74. PMID:9875850
Page seeded by OCA on Thu Mar 20 13:15:19 2008
