1ouw

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[[Image:1ouw.gif|left|200px]]<br /><applet load="1ouw" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ouw.gif|left|200px]]
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caption="1ouw, resolution 1.37&Aring;" />
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'''Crystal structure of Calystegia sepium agglutinin'''<br />
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{{Structure
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|PDB= 1ouw |SIZE=350|CAPTION= <scene name='initialview01'>1ouw</scene>, resolution 1.37&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MLT:MALATE+ION'>MLT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene> and <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of Calystegia sepium agglutinin'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1OUW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Calystegia_sepium Calystegia sepium] with <scene name='pdbligand=MLT:'>MLT</scene>, <scene name='pdbligand=EDO:'>EDO</scene> and <scene name='pdbligand=IMD:'>IMD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OUW OCA].
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1OUW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Calystegia_sepium Calystegia sepium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OUW OCA].
==Reference==
==Reference==
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The crystal structure of the Calystegia sepium agglutinin reveals a novel quaternary arrangement of lectin subunits with a beta-prism fold., Bourne Y, Roig-Zamboni V, Barre A, Peumans WJ, Astoul CH, Van Damme EJ, Rouge P, J Biol Chem. 2004 Jan 2;279(1):527-33. Epub 2003 Oct 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14561768 14561768]
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The crystal structure of the Calystegia sepium agglutinin reveals a novel quaternary arrangement of lectin subunits with a beta-prism fold., Bourne Y, Roig-Zamboni V, Barre A, Peumans WJ, Astoul CH, Van Damme EJ, Rouge P, J Biol Chem. 2004 Jan 2;279(1):527-33. Epub 2003 Oct 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14561768 14561768]
[[Category: Calystegia sepium]]
[[Category: Calystegia sepium]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: mannose-binding]]
[[Category: mannose-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:21:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:15:55 2008''

Revision as of 11:15, 20 March 2008

Image:1ouw.gif


PDB ID 1ouw

Drag the structure with the mouse to rotate
, resolution 1.37Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



Crystal structure of Calystegia sepium agglutinin


Overview

The high number of quaternary structures observed for lectins highlights the important role of these oligomeric assemblies during carbohydrate recognition events. Although a large diversity in the mode of association of lectin subunits is frequently observed, the oligomeric assemblies of plant lectins display small variations within a single family. The crystal structure of the mannose-binding jacalin-related lectin from Calystegia sepium (Calsepa) has been determined at 1.37-A resolution. Calsepa exhibits the same beta-prism fold as identified previously for other members of the family, but the shape and the hydrophobic character of its carbohydrate-binding site is unlike that of other members, consistent with surface plasmon resonance analysis showing a preference for methylated sugars. Calsepa reveals a novel dimeric assembly markedly dissimilar to those described earlier for Heltuba and jacalin but mimics the canonical 12-stranded beta-sandwich dimer found in legume lectins. The present structure exemplifies the adaptability of the beta-prism building block in the evolution of plant lectins and highlights the biological role of these quaternary structures for carbohydrate recognition.

About this Structure

1OUW is a Single protein structure of sequence from Calystegia sepium. Full crystallographic information is available from OCA.

Reference

The crystal structure of the Calystegia sepium agglutinin reveals a novel quaternary arrangement of lectin subunits with a beta-prism fold., Bourne Y, Roig-Zamboni V, Barre A, Peumans WJ, Astoul CH, Van Damme EJ, Rouge P, J Biol Chem. 2004 Jan 2;279(1):527-33. Epub 2003 Oct 15. PMID:14561768

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