1ovl

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[[Image:1ovl.gif|left|200px]]<br /><applet load="1ovl" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ovl.gif|left|200px]]
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caption="1ovl, resolution 2.2&Aring;" />
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'''Crystal Structure of Nurr1 LBD'''<br />
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{{Structure
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|PDB= 1ovl |SIZE=350|CAPTION= <scene name='initialview01'>1ovl</scene>, resolution 2.2&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene> and <scene name='pdbligand=IOD:IODIDE ION'>IOD</scene>
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|ACTIVITY=
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|GENE= NR4A2 OR NURR1 OR TINUR OR NOT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Crystal Structure of Nurr1 LBD'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1OVL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=K:'>K</scene>, <scene name='pdbligand=BR:'>BR</scene> and <scene name='pdbligand=IOD:'>IOD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OVL OCA].
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1OVL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OVL OCA].
==Reference==
==Reference==
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Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors., Wang Z, Benoit G, Liu J, Prasad S, Aarnisalo P, Liu X, Xu H, Walker NP, Perlmann T, Nature. 2003 May 29;423(6939):555-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12774125 12774125]
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Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors., Wang Z, Benoit G, Liu J, Prasad S, Aarnisalo P, Liu X, Xu H, Walker NP, Perlmann T, Nature. 2003 May 29;423(6939):555-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12774125 12774125]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: nuur1]]
[[Category: nuur1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:22:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:16:08 2008''

Revision as of 11:16, 20 March 2008

Image:1ovl.gif


PDB ID 1ovl

Drag the structure with the mouse to rotate
, resolution 2.2Å
Ligands: , and
Gene: NR4A2 OR NURR1 OR TINUR OR NOT (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Nurr1 LBD


Contents

Overview

Members of the nuclear receptor (NR) superfamily of transcription factors modulate gene transcription in response to small lipophilic molecules. Transcriptional activity is regulated by ligands binding to the carboxy-terminal ligand-binding domains (LBDs) of cognate NRs. A subgroup of NRs referred to as 'orphan receptors' lack identified ligands, however, raising issues about the function of their LBDs. Here we report the crystal structure of the LBD of the orphan receptor Nurr1 at 2.2 A resolution. The Nurr1 LBD adopts a canonical protein fold resembling that of agonist-bound, transcriptionally active LBDs in NRs, but the structure has two distinctive features. First, the Nurr1 LBD contains no cavity as a result of the tight packing of side chains from several bulky hydrophobic residues in the region normally occupied by ligands. Second, Nurr1 lacks a 'classical' binding site for coactivators. Despite these differences, the Nurr1 LBD can be regulated in mammalian cells. Notably, transcriptional activity is correlated with the Nurr1 LBD adopting a more stable conformation. Our findings highlight a unique structural class of NRs and define a model for ligand-independent NR function.

Disease

Known diseases associated with this structure: Parkinson disease OMIM:[601828]

About this Structure

1OVL is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors., Wang Z, Benoit G, Liu J, Prasad S, Aarnisalo P, Liu X, Xu H, Walker NP, Perlmann T, Nature. 2003 May 29;423(6939):555-60. PMID:12774125

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