1cd8

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m (Protected "1cd8" [edit=sysop:move=sysop])
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[[Image:1cd8.png|left|200px]]
 
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{{STRUCTURE_1cd8| PDB=1cd8 | SCENE= }}
{{STRUCTURE_1cd8| PDB=1cd8 | SCENE= }}
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===CRYSTAL STRUCTURE OF A SOLUBLE FORM OF THE HUMAN T CELL CO-RECEPTOR CD8 AT 2.6 ANGSTROMS RESOLUTION===
===CRYSTAL STRUCTURE OF A SOLUBLE FORM OF THE HUMAN T CELL CO-RECEPTOR CD8 AT 2.6 ANGSTROMS RESOLUTION===
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{{ABSTRACT_PUBMED_1547508}}
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{{ABSTRACT_PUBMED_1547508}}
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==Disease==
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[[http://www.uniprot.org/uniprot/CD8A_HUMAN CD8A_HUMAN]] Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:[http://omim.org/entry/608957 608957]]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
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==Function==
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[[http://www.uniprot.org/uniprot/CD8A_HUMAN CD8A_HUMAN]] Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:001547508</ref><ref group="xtra">PMID:009177355</ref><references group="xtra"/>
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<ref group="xtra">PMID:001547508</ref><ref group="xtra">PMID:009177355</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Axel, R.]]
[[Category: Axel, R.]]

Revision as of 09:40, 24 March 2013

Template:STRUCTURE 1cd8

Contents

CRYSTAL STRUCTURE OF A SOLUBLE FORM OF THE HUMAN T CELL CO-RECEPTOR CD8 AT 2.6 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 1547508

Disease

[CD8A_HUMAN] Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

Function

[CD8A_HUMAN] Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

About this Structure

1cd8 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Leahy DJ, Axel R, Hendrickson WA. Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution. Cell. 1992 Mar 20;68(6):1145-62. PMID:1547508
  • Gao GF, Tormo J, Gerth UC, Wyer JR, McMichael AJ, Stuart DI, Bell JI, Jones EY, Jakobsen BK. Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2. Nature. 1997 Jun 5;387(6633):630-4. PMID:9177355 doi:http://dx.doi.org/10.1038/42523

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