1ozs
From Proteopedia
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| - | [[Image:1ozs.jpg|left|200px]]< | + | [[Image:1ozs.jpg|left|200px]] |
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| - | '''C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I''' | + | {{Structure |
| + | |PDB= 1ozs |SIZE=350|CAPTION= <scene name='initialview01'>1ozs</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= TNNC1 OR TNNC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), TNNI3 OR TNNC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==Disease== | ==Disease== | ||
| - | Known diseases associated with this structure: Cardiomyopathy, familial hypertrophic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191044 191044]], Cardiomyopathy, familial hypertrophic, 192600 (3) OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191040 191040]], Cardiomyopathy, familial restrictive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191044 191044]] | + | Known diseases associated with this structure: Cardiomyopathy, dilated, 1Z OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191040 191040]], Cardiomyopathy, dilated, 2A OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191044 191044]], Cardiomyopathy, familial hypertrophic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191044 191044]], Cardiomyopathy, familial hypertrophic, 192600 (3) OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191040 191040]], Cardiomyopathy, familial restrictive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191044 191044]] |
==About this Structure== | ==About this Structure== | ||
| - | 1OZS is a [ | + | 1OZS is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZS OCA]. |
==Reference== | ==Reference== | ||
| - | Structure and dynamics of the C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I., Lindhout DA, Sykes BD, J Biol Chem. 2003 Jul 18;278(29):27024-34. Epub 2003 May 5. PMID:[http:// | + | Structure and dynamics of the C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I., Lindhout DA, Sykes BD, J Biol Chem. 2003 Jul 18;278(29):27024-34. Epub 2003 May 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12732641 12732641] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: ef-hand]] | [[Category: ef-hand]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:17:51 2008'' |
Revision as of 11:17, 20 March 2008
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| Ligands: | |||||||
| Gene: | TNNC1 OR TNNC (Homo sapiens), TNNI3 OR TNNC1 (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I
Contents |
Overview
Cardiac troponin C is the Ca2+-dependent switch for heart muscle contraction. Troponin C is associated with various other proteins including troponin I and troponin T. The interaction between the subunits within the troponin complex is of critical importance in understanding contractility. Following a Ca2+ signal to begin contraction, the inhibitory region of troponin I comprising residues Thr128-Arg147 relocates from its binding surface on actin to troponin C, triggering movement of troponin-tropomyosin within the thin filament and thereby freeing actin-binding site(s) for interactions with the myosin ATPase of the thick filament to generate the power stroke. The structure of calcium-saturated cardiac troponin C (C-domain) in complex with the inhibitory region of troponin I was determined using multinuclear and multidimensional nuclear magnetic resonance spectroscopy. The structure of this complex reveals that the inhibitory region adopts a helical conformation spanning residues Leu134-Lys139, with a novel orientation between the E- and H-helices of troponin C, which is largely stabilized by electrostatic interactions. By using isotope labeling, we have studied the dynamics of the protein and peptide in the binary complex. The structure of this inhibited complex provides a framework for understanding into interactions within the troponin complex upon heart contraction.
Disease
Known diseases associated with this structure: Cardiomyopathy, dilated, 1Z OMIM:[191040], Cardiomyopathy, dilated, 2A OMIM:[191044], Cardiomyopathy, familial hypertrophic OMIM:[191044], Cardiomyopathy, familial hypertrophic, 192600 (3) OMIM:[191040], Cardiomyopathy, familial restrictive OMIM:[191044]
About this Structure
1OZS is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure and dynamics of the C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I., Lindhout DA, Sykes BD, J Biol Chem. 2003 Jul 18;278(29):27024-34. Epub 2003 May 5. PMID:12732641
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