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2bb5

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[[Image:2bb5.png|left|200px]]
 
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{{STRUCTURE_2bb5| PDB=2bb5 | SCENE= }}
{{STRUCTURE_2bb5| PDB=2bb5 | SCENE= }}
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===Structure of Human Transcobalamin in complex with Cobalamin===
===Structure of Human Transcobalamin in complex with Cobalamin===
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{{ABSTRACT_PUBMED_16537422}}
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{{ABSTRACT_PUBMED_16537422}}
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==Disease==
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[[http://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:[http://omim.org/entry/275350 275350]]. This results in various forms of anemia.
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==Function==
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[[http://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:016537422</ref><references group="xtra"/>
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<ref group="xtra">PMID:016537422</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Fedosov, S N.]]
[[Category: Fedosov, S N.]]

Revision as of 00:44, 25 March 2013

Template:STRUCTURE 2bb5

Contents

Structure of Human Transcobalamin in complex with Cobalamin

Template:ABSTRACT PUBMED 16537422

Disease

[TCO2_HUMAN] Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:275350]. This results in various forms of anemia.

Function

[TCO2_HUMAN] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.

About this Structure

2bb5 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Wuerges J, Garau G, Geremia S, Fedosov SN, Petersen TE, Randaccio L. Structural basis for mammalian vitamin B12 transport by transcobalamin. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4386-91. Epub 2006 Mar 14. PMID:16537422

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