4hhf

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'''Unreleased structure'''
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{{STRUCTURE_4hhf| PDB=4hhf | SCENE= }}
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===Crystal Structure of chemically synthesized scorpion alpha-toxin OD1===
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{{ABSTRACT_PUBMED_23527544}}
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The entry 4hhf is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/SCX1_ODODO SCX1_ODODO]] Alpha toxins bind voltage-independently at site-3 of sodium channels and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Mammalian sodium channels Nav1.5/SCN2A (only at micromolar concentrations), Nav1.7/SCN9A (EC(50)=4.5 nM) and insect sodium channel para/tipE (EC(50)=80 nM) are affected by this toxin, whereas mammalian sodium channels Nav1.2/SCN2A, Nav1.3/SCN3A, and Nav1.8/SCN10A are unaffected by high concentrations.<ref>PMID:16038905</ref> <ref>PMID:16641312</ref>
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Authors: Wang, C.I.A., Lewis, R.J., Alewood, P.F., Durek, T.
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==About this Structure==
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[[4hhf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHF OCA].
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Description: Crystal Structure of chemically synthesized scorpion alpha-toxin OD1
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Alewood, P F.]]
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[[Category: Durek, T.]]
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[[Category: Lewis, R J.]]
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[[Category: Wang, C I.A.]]
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[[Category: 1 6]]
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[[Category: 1 7]]
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[[Category: C-terminally amidated]]
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[[Category: Gating modulator]]
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[[Category: Inhibition of fast channel inactivation]]
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[[Category: Scorpion long-chain alpha-toxin]]
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[[Category: Toxin]]
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[[Category: Venom gland]]
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[[Category: Voltage-gated sodium channels 1 4]]

Revision as of 11:22, 24 April 2013

Template:STRUCTURE 4hhf

Contents

Crystal Structure of chemically synthesized scorpion alpha-toxin OD1

Template:ABSTRACT PUBMED 23527544

Function

[SCX1_ODODO] Alpha toxins bind voltage-independently at site-3 of sodium channels and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Mammalian sodium channels Nav1.5/SCN2A (only at micromolar concentrations), Nav1.7/SCN9A (EC(50)=4.5 nM) and insect sodium channel para/tipE (EC(50)=80 nM) are affected by this toxin, whereas mammalian sodium channels Nav1.2/SCN2A, Nav1.3/SCN3A, and Nav1.8/SCN10A are unaffected by high concentrations.[1] [2]

About this Structure

4hhf is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Jalali A, Bosmans F, Amininasab M, Clynen E, Cuypers E, Zaremirakabadi A, Sarbolouki MN, Schoofs L, Vatanpour H, Tytgat J. OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na+ channels. FEBS Lett. 2005 Aug 1;579(19):4181-6. PMID:16038905 doi:S0014-5793(05)00797-0
  2. ↑ Maertens C, Cuypers E, Amininasab M, Jalali A, Vatanpour H, Tytgat J. Potent modulation of the voltage-gated sodium channel Nav1.7 by OD1, a toxin from the scorpion Odonthobuthus doriae. Mol Pharmacol. 2006 Jul;70(1):405-14. Epub 2006 Apr 26. PMID:16641312 doi:mol.106.022970

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