1p9f
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1p9f.jpg|left|200px]] | + | [[Image:1p9f.jpg|left|200px]] |
| - | + | ||
| - | '''NMR Structure of Neurokinin B from DYANA''' | + | {{Structure |
| + | |PDB= 1p9f |SIZE=350|CAPTION= <scene name='initialview01'>1p9f</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''NMR Structure of Neurokinin B from DYANA''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1P9F is a [ | + | 1P9F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9F OCA]. |
==Reference== | ==Reference== | ||
| - | Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles., Mantha AK, Chandrashekar IR, Baquer NZ, Cowsik SM, J Biomol Struct Dyn. 2004 Oct;22(2):137-48. PMID:[http:// | + | Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles., Mantha AK, Chandrashekar IR, Baquer NZ, Cowsik SM, J Biomol Struct Dyn. 2004 Oct;22(2):137-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15317475 15317475] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Baquer, N Z.]] | [[Category: Baquer, N Z.]] | ||
| Line 20: | Line 29: | ||
[[Category: structures from dyana]] | [[Category: structures from dyana]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:21:39 2008'' |
Revision as of 11:21, 20 March 2008
| |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR Structure of Neurokinin B from DYANA
Overview
Neurokinin B (NKB), a decapeptide of mammalian origin exhibits a variety of biological activities such as regulatory functions in reproduction, pre-eclampsia and neuroprotection in Alzheimer's disease. In order to gain insight into structure-function relationship, three-dimensional structure of NKB has been investigated using CD spectropolarimetry and two-dimensional proton nuclear magnetic resonance (2D 1H-NMR) spectroscopy in aqueous and membrane mimetic solvents. Unambiguous NMR assignments of resonances have been made with the aid of correlation spectroscopy (DQF-COSY and TOCSY) experiments and Nuclear Overhauser Effect Spectroscopy (NOESY) experiments. Distance constraints obtained from the NMR data have been used to generate a family of structures, which have been refined using restrained energy minimization and dynamics. Our data show that a helical structure is induced in NKB, in presence of perdeuterated dodecyl phosphocholine (DPC) micelles, a membrane model system. Further, the conformation adopted by NKB in presence of DPC micelles represents a structural motif typical of neurokinin-3 selective agonists.
About this Structure
1P9F is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles., Mantha AK, Chandrashekar IR, Baquer NZ, Cowsik SM, J Biomol Struct Dyn. 2004 Oct;22(2):137-48. PMID:15317475
Page seeded by OCA on Thu Mar 20 13:21:39 2008
