1p9x

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[[Image:1p9x.gif|left|200px]]<br /><applet load="1p9x" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1p9x.gif|left|200px]]
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caption="1p9x, resolution 3.40&Aring;" />
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'''THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC'''<br />
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{{Structure
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|PDB= 1p9x |SIZE=350|CAPTION= <scene name='initialview01'>1p9x</scene>, resolution 3.40&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=TEL:TELITHROMYCIN'>TEL</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1P9X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] with <scene name='pdbligand=TEL:'>TEL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9X OCA].
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1P9X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9X OCA].
==Reference==
==Reference==
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Structural insight into the antibiotic action of telithromycin against resistant mutants., Berisio R, Harms J, Schluenzen F, Zarivach R, Hansen HA, Fucini P, Yonath A, J Bacteriol. 2003 Jul;185(14):4276-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12837804 12837804]
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Structural insight into the antibiotic action of telithromycin against resistant mutants., Berisio R, Harms J, Schluenzen F, Zarivach R, Hansen HA, Fucini P, Yonath A, J Bacteriol. 2003 Jul;185(14):4276-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12837804 12837804]
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: ketolide]]
[[Category: ketolide]]
[[Category: macrolide]]
[[Category: macrolide]]
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[[Category: ribosomes]]
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[[Category: ribosome]]
[[Category: trna]]
[[Category: trna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:26:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:21:49 2008''

Revision as of 11:21, 20 March 2008

Image:1p9x.gif


PDB ID 1p9x

Drag the structure with the mouse to rotate
, resolution 3.40Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC


Overview

The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.

About this Structure

1P9X is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

Structural insight into the antibiotic action of telithromycin against resistant mutants., Berisio R, Harms J, Schluenzen F, Zarivach R, Hansen HA, Fucini P, Yonath A, J Bacteriol. 2003 Jul;185(14):4276-9. PMID:12837804

Page seeded by OCA on Thu Mar 20 13:21:49 2008

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