2m01

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'''Unreleased structure'''
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{{STRUCTURE_2m01| PDB=2m01 | SCENE= }}
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===Solution structure of Kunitz-type neurotoxin LmKKT-1a from scorpion venom===
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{{ABSTRACT_PUBMED_23573241}}
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The entry 2m01 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/VPI1B_LYCMC VPI1B_LYCMC]] The recombinant protein has two functions. It completely inhibits trypsin activity at a molar ratio of 1:1 with a dissociation constant of 140 nM and also inhibits mKv1.3/KCNA3 potassium channel currents (1 uM inhibits 50% of currents).<ref>PMID:22087336</ref> <ref>PMID:22354971</ref>
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Authors: Luo, F., Jiang, L., Liu, M., Chen, Z., Wu, Y.
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==About this Structure==
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[[2m01]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M01 OCA].
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Description: Solution structure of Kunitz-type neurotoxin LmKKT-1a from scorpion venom
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==Reference==
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<ref group="xtra">PMID:023573241</ref><references group="xtra"/><references/>
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[[Category: Chen, Z.]]
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[[Category: Jiang, L.]]
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[[Category: Liu, M.]]
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[[Category: Luo, F.]]
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[[Category: Wu, Y.]]
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[[Category: Kunitz-type neurotoxin]]
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[[Category: Scorpion potassium channel toxin]]
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[[Category: Toxin]]

Revision as of 08:15, 13 November 2013

Template:STRUCTURE 2m01

Contents

Solution structure of Kunitz-type neurotoxin LmKKT-1a from scorpion venom

Template:ABSTRACT PUBMED 23573241

Function

[VPI1B_LYCMC] The recombinant protein has two functions. It completely inhibits trypsin activity at a molar ratio of 1:1 with a dissociation constant of 140 nM and also inhibits mKv1.3/KCNA3 potassium channel currents (1 uM inhibits 50% of currents).[1] [2]

About this Structure

2m01 is a 1 chain structure. Full experimental information is available from OCA.

Reference

  • Chen Z, Luo F, Feng J, Yang W, Zeng D, Zhao R, Cao Z, Liu M, Li W, Jiang L, Wu Y. Genomic and structural characterization of Kunitz-type peptide LmKTT-1a highlights diversity and evolution of scorpion potassium channel toxins. PLoS One. 2013;8(4):e60201. doi: 10.1371/journal.pone.0060201. Epub 2013 Apr 3. PMID:23573241 doi:http://dx.doi.org/10.1371/journal.pone.0060201
  1. ↑ Zhao R, Dai H, Qiu S, Li T, He Y, Ma Y, Chen Z, Wu Y, Li W, Cao Z. SdPI, the first functionally characterized Kunitz-type trypsin inhibitor from scorpion venom. PLoS One. 2011;6(11):e27548. doi: 10.1371/journal.pone.0027548. Epub 2011 Nov 8. PMID:22087336 doi:http://dx.doi.org/10.1371/journal.pone.0027548
  2. ↑ Chen ZY, Hu YT, Yang WS, He YW, Feng J, Wang B, Zhao RM, Ding JP, Cao ZJ, Li WX, Wu YL. Hg1, novel peptide inhibitor specific for Kv1.3 channels from first scorpion Kunitz-type potassium channel toxin family. J Biol Chem. 2012 Apr 20;287(17):13813-21. doi: 10.1074/jbc.M112.343996. Epub, 2012 Feb 21. PMID:22354971 doi:http://dx.doi.org/10.1074/jbc.M112.343996

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