4hmr

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'''Unreleased structure'''
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{{STRUCTURE_4hmr| PDB=4hmr | SCENE= }}
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===Crystal structure of mutant rabbit PRP 121-230 (S170N/S174N)===
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The entry 4hmr is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/PRIO_RABIT PRIO_RABIT]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
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Authors: Sweeting, B., Chakrabartty, A., Pai, E.F.
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==Function==
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[[http://www.uniprot.org/uniprot/PRIO_RABIT PRIO_RABIT]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
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Description: Crystal structure of mutant rabbit PRP 121-230 (S170N/S174N)
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==About this Structure==
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[[4hmr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMR OCA].
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[[Category: Oryctolagus cuniculus]]
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[[Category: Chakrabartty, A.]]
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[[Category: Pai, E F.]]
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[[Category: Sweeting, B.]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Prion]]
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[[Category: Prp]]

Revision as of 07:31, 16 May 2013

Template:STRUCTURE 4hmr

Contents

Crystal structure of mutant rabbit PRP 121-230 (S170N/S174N)

Disease

[PRIO_RABIT] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.

Function

[PRIO_RABIT] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

About this Structure

4hmr is a 2 chain structure with sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

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OCA

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