1pkq
From Proteopedia
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| - | [[Image:1pkq.gif|left|200px]] | + | [[Image:1pkq.gif|left|200px]] |
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| - | '''Myelin Oligodendrocyte Glycoprotein-(8-18C5) Fab-complex''' | + | {{Structure |
| + | |PDB= 1pkq |SIZE=350|CAPTION= <scene name='initialview01'>1pkq</scene>, resolution 3.0Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= Ig light chain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Ig heavy chain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), MOG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | ||
| + | }} | ||
| + | |||
| + | '''Myelin Oligodendrocyte Glycoprotein-(8-18C5) Fab-complex''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1PKQ is a [ | + | 1PKQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKQ OCA]. |
==Reference== | ==Reference== | ||
| - | Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein., Breithaupt C, Schubart A, Zander H, Skerra A, Huber R, Linington C, Jacob U, Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9446-51. Epub 2003 Jul 21. PMID:[http:// | + | Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein., Breithaupt C, Schubart A, Zander H, Skerra A, Huber R, Linington C, Jacob U, Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9446-51. Epub 2003 Jul 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12874380 12874380] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
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[[Category: multiple sclerosis]] | [[Category: multiple sclerosis]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:25:38 2008'' |
Revision as of 11:25, 20 March 2008
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| , resolution 3.0Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | Ig light chain (Mus musculus), Ig heavy chain (Mus musculus), MOG (Rattus norvegicus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Myelin Oligodendrocyte Glycoprotein-(8-18C5) Fab-complex
Overview
Multiple sclerosis is a chronic disease of the central nervous system (CNS) characterized by inflammation, demyelination, and axonal loss. The immunopathogenesis of demyelination in multiple sclerosis involves an autoantibody response to myelin oligodendrocyte glycoprotein (MOG), a type I transmembrane protein located at the surface of CNS myelin. Here we present the crystal structures of the extracellular domain of MOG (MOGIgd) at 1.45-A resolution and the complex of MOGIgd with the antigen-binding fragment (Fab) of the MOG-specific demyelinating monoclonal antibody 8-18C5 at 3.0-A resolution. MOGIgd adopts an IgV like fold with the A'GFCC'C" sheet harboring a cavity similar to the one used by the costimulatory molecule B7-2 to bind its ligand CTLA4. The antibody 8-18C5 binds to three loops located at the membrane-distal side of MOG with a surprisingly dominant contribution made by MOG residues 101-108 containing a strained loop that forms the upper edge of the putative ligand binding site. The sequence R101DHSYQEE108 is unique for MOG, whereas large parts of the remaining sequence are conserved in potentially tolerogenic MOG homologues expressed outside the immuno-privileged environment of the CNS. Strikingly, the only sequence identical to DHSYQEE was found in a Chlamydia trachomatis protein of unknown function, raising the possibility that Chlamydia infections may play a role in the MOG-specific autoimmune response in man. Our data provide the structural basis for the development of diagnostic and therapeutic strategies targeting the pathogenic autoantibody response to MOG.
About this Structure
1PKQ is a Single protein structure of sequence from Mus musculus and Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein., Breithaupt C, Schubart A, Zander H, Skerra A, Huber R, Linington C, Jacob U, Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9446-51. Epub 2003 Jul 21. PMID:12874380
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