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1dsu
From Proteopedia
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| - | [[Image:1dsu.png|left|200px]] | ||
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{{STRUCTURE_1dsu| PDB=1dsu | SCENE= }} | {{STRUCTURE_1dsu| PDB=1dsu | SCENE= }} | ||
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===HUMAN FACTOR D, COMPLEMENT ACTIVATING ENZYME=== | ===HUMAN FACTOR D, COMPLEMENT ACTIVATING ENZYME=== | ||
| + | {{ABSTRACT_PUBMED_8289289}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN]] Defects in CFD are the cause of complement factor D deficiency (CFDD) [MIM:[http://omim.org/entry/613912 613912]]. CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway. | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN]] Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:008289289</ref><references group="xtra"/> | + | <ref group="xtra">PMID:008289289</ref><references group="xtra"/><references/> |
[[Category: Complement factor D]] | [[Category: Complement factor D]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 05:39, 25 March 2013
Contents |
HUMAN FACTOR D, COMPLEMENT ACTIVATING ENZYME
Template:ABSTRACT PUBMED 8289289
Disease
[CFAD_HUMAN] Defects in CFD are the cause of complement factor D deficiency (CFDD) [MIM:613912]. CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.
Function
[CFAD_HUMAN] Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
About this Structure
1dsu is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Narayana SV, Carson M, el-Kabbani O, Kilpatrick JM, Moore D, Chen X, Bugg CE, Volanakis JE, DeLucas LJ. Structure of human factor D. A complement system protein at 2.0 A resolution. J Mol Biol. 1994 Jan 14;235(2):695-708. PMID:8289289
