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1pnn

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[[Image:1pnn.gif|left|200px]]<br /><applet load="1pnn" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1pnn.gif|left|200px]]
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caption="1pnn, resolution 2.5&Aring;" />
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'''PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA'''<br />
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{{Structure
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|PDB= 1pnn |SIZE=350|CAPTION= <scene name='initialview01'>1pnn</scene>, resolution 2.5&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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'''PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1PNN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PNN OCA].
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1PNN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PNN OCA].
==Reference==
==Reference==
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A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex., Betts L, Josey JA, Veal JM, Jordan SR, Science. 1995 Dec 15;270(5243):1838-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8525381 8525381]
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A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex., Betts L, Josey JA, Veal JM, Jordan SR, Science. 1995 Dec 15;270(5243):1838-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8525381 8525381]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Betts, L.]]
[[Category: Betts, L.]]
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[[Category: triplex watson-crick hoogsteen]]
[[Category: triplex watson-crick hoogsteen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:30:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:26:37 2008''

Revision as of 11:26, 20 March 2008

Image:1pnn.gif


PDB ID 1pnn

Drag the structure with the mouse to rotate
, resolution 2.5Å
Coordinates: save as pdb, mmCIF, xml



PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA


Overview

The crystal structure of a nucleic acid triplex reveals a helix, designated P-form, that differs from previously reported nucleic acid structures. The triplex consists of one polypurine DNA strand complexed to a polypyrimidine hairpin peptide nucleic acid (PNA) and was successfully designed to promote Watson-Crick and Hoogsteen base pairing. The P-form helix is underwound, with a base tilt similar to B-form DNA. The bases are displaced from the helix axis even more than in A-form DNA. Hydrogen bonds between the DNA backbone and the Hoogsteen PNA backbone explain the observation that polypyrimidine PNA sequences form highly stable 2:1 PNA-DNA complexes. This structure expands the number of known stable helical forms that nucleic acids can adopt.

About this Structure

1PNN is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex., Betts L, Josey JA, Veal JM, Jordan SR, Science. 1995 Dec 15;270(5243):1838-41. PMID:8525381

Page seeded by OCA on Thu Mar 20 13:26:37 2008

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