Lactoperoxidase
From Proteopedia
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==3D structures of lactoperoxidase== | ==3D structures of lactoperoxidase== | ||
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| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
'''Lactoperoxidase binary complex''' | '''Lactoperoxidase binary complex''' | ||
[[2pt3]] - bPLO + phosphate - bovine<br /> | [[2pt3]] - bPLO + phosphate - bovine<br /> | ||
| + | [[2nqx]] – bPLO + I<br /> | ||
[[2r5l]] – gLPO + I – goat<br /> | [[2r5l]] – gLPO + I – goat<br /> | ||
| - | [[3nak]] – gLPO + formate | + | [[3nak]] – gLPO + formate<br /> |
| + | [[4ig5]] – gLPO + methimazole<br /> | ||
'''Lactoperoxidase ternary complex''' | '''Lactoperoxidase ternary complex''' | ||
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[[2qrb]] – bLPO + SCN + Cl<br /> | [[2qrb]] – bLPO + SCN + Cl<br /> | ||
[[3bxi]] – bLPO + SCN + nitrate<br /> | [[3bxi]] – bLPO + SCN + nitrate<br /> | ||
| + | [[4pnx]] - bPLO + bromomethane + I<br /> | ||
[[2pum]] – bPLO + catechol + I<br /> | [[2pum]] – bPLO + catechol + I<br /> | ||
[[2gj1]] – bLPO + carbonate + nitrate <br /> | [[2gj1]] – bLPO + carbonate + nitrate <br /> | ||
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[[3gcj]], [[2qpk]] - bPLO + salicylhydroxamic acid + SCN + I<br /> | [[3gcj]], [[2qpk]] - bPLO + salicylhydroxamic acid + SCN + I<br /> | ||
[[3gck]] - bPLO + benzylhydroxamic acid + SCN + I<br /> | [[3gck]] - bPLO + benzylhydroxamic acid + SCN + I<br /> | ||
| - | [[3uba]] - bPLO + hydroxycinnamic acid + SCN + I<br /> | + | [[3uba]], [[4gm7]] - bPLO + hydroxycinnamic acid + SCN + I<br /> |
[[3gcl]], [[2qqt]] - bPLO + aspirin + SCN + I<br /> | [[3gcl]], [[2qqt]] - bPLO + aspirin + SCN + I<br /> | ||
[[3i6n]] - bPLO + isoniazid + SCN + I<br /> | [[3i6n]] - bPLO + isoniazid + SCN + I<br /> | ||
| + | [[4ksz]] - bPLO + cystein + SCN + I<br /> | ||
[[3nyh]] - bPLO + Br + Cl + SCN + I<br /> | [[3nyh]] - bPLO + Br + Cl + SCN + I<br /> | ||
[[3ogw]] - bPLO + indomethacin + SCN + I<br /> | [[3ogw]] - bPLO + indomethacin + SCN + I<br /> | ||
| - | [[3py4]] - bPLO + paracetamol + SCN + I<br /> | + | [[3py4]], [[4gn6]] - bPLO + paracetamol + SCN + I<br /> |
[[3q9k]] - bPLO + phenyliso-SCN + SCN + I<br /> | [[3q9k]] - bPLO + phenyliso-SCN + SCN + I<br /> | ||
[[3ql6]] - bPLO + nitro-phenoxymethanesulfonanilide+ SCN + I<br /> | [[3ql6]] - bPLO + nitro-phenoxymethanesulfonanilide+ SCN + I<br /> | ||
| - | [[3s4f]] - bPLO + pyridine derivative + SCN + I<br /> | + | [[3s4f]], [[4njb]], [[4nt3]] - bPLO + pyridine derivative + SCN + I<br /> |
[[3r4x]], [[3tuw]] - bPLO + pyrazine derivative + SCN + I<br /> | [[3r4x]], [[3tuw]] - bPLO + pyrazine derivative + SCN + I<br /> | ||
[[3r5o]] - bPLO + methoxyphenol + SCN + I<br /> | [[3r5o]] - bPLO + methoxyphenol + SCN + I<br /> | ||
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[[2efb]] – gPLO + phosphate + carbonate + SCN + CN<br /> | [[2efb]] – gPLO + phosphate + carbonate + SCN + CN<br /> | ||
[[3qf1]] - gPLO + piperazine + SCN + I<br /> | [[3qf1]] - gPLO + piperazine + SCN + I<br /> | ||
| + | [[4ljj]] - gPLO + acrylonitrile + SCN + I<br /> | ||
| + | [[4msf]], [[4oek]] - gPLO + phenol derivative+ SCN + I<br /> | ||
[[2eha]] – gPLO + formate + carbonate + SCN<br /> | [[2eha]] – gPLO + formate + carbonate + SCN<br /> | ||
| - | [[3r55]] - gPLO + pyrazine derivative + SCN + I<br /> | + | [[3r55]], [[4n7a]] - gPLO + pyrazine derivative + SCN + I<br /> |
[[3sxv]] - gPLO + amitrole + SCN + I<br /> | [[3sxv]] - gPLO + amitrole + SCN + I<br /> | ||
[[3r5q]] - sPLO +tetrahydrofuran + SCN + I<br /> | [[3r5q]] - sPLO +tetrahydrofuran + SCN + I<br /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:33, 20 March 2014
Lactoperoxidase (LPO) catalyzes the oxidation of thiocyanate, bromide and iodide using hydrogen peroxide. The short-lived oxidized intermediates of the reaction serve as potent bactericidal agents. LPO is used as an antimicrobial agent in milk and its products, in cosmetics, toothpaste and ophthalmic solutions. LPO is the second most abundant enzyme in milk. Heme is the cofactor of LPO. LPO contains a strongly-chelated calcium ion.
3D structures of lactoperoxidase
Updated on 20-March-2014
Lactoperoxidase binary complex
2pt3 - bPLO + phosphate - bovine
2nqx – bPLO + I
2r5l – gLPO + I – goat
3nak – gLPO + formate
4ig5 – gLPO + methimazole
Lactoperoxidase ternary complex
2gj1 – bLPO + carbonate + nitrate
2ips, 3eri, 3gc1 – bLPO + SCN + I
2qrb – bLPO + SCN + Cl
3bxi – bLPO + SCN + nitrate
4pnx - bPLO + bromomethane + I
2pum – bPLO + catechol + I
2gj1 – bLPO + carbonate + nitrate
3krq – bLPO + amino-triazole + I
2z5z – wbPLO + F + I – water buffalo
2o86 – wbPLO + nitrate + I
3erh - wbLPO + SCN + I
2ojv – gPLO + CN + I
3n8f - gLPO + SCN + nitrate
3niu – gLPO + diethylene glycol + phosphate
3rke - gPLO + inhibitor + I
2ikc – sLPO + carbonate + formate – sheep
Lactoperoxidase quaternary complex
3gcj, 2qpk - bPLO + salicylhydroxamic acid + SCN + I
3gck - bPLO + benzylhydroxamic acid + SCN + I
3uba, 4gm7 - bPLO + hydroxycinnamic acid + SCN + I
3gcl, 2qqt - bPLO + aspirin + SCN + I
3i6n - bPLO + isoniazid + SCN + I
4ksz - bPLO + cystein + SCN + I
3nyh - bPLO + Br + Cl + SCN + I
3ogw - bPLO + indomethacin + SCN + I
3py4, 4gn6 - bPLO + paracetamol + SCN + I
3q9k - bPLO + phenyliso-SCN + SCN + I
3ql6 - bPLO + nitro-phenoxymethanesulfonanilide+ SCN + I
3s4f, 4njb, 4nt3 - bPLO + pyridine derivative + SCN + I
3r4x, 3tuw - bPLO + pyrazine derivative + SCN + I
3r5o - bPLO + methoxyphenol + SCN + I
3tgy - bPLO + ascorbate + SCN + I
3v6q - bPLO + CO + SCN + I
2gjm - wbPLO + carbonate + SCN + I
3faq – wbLPO + CN + SCN + I
3fnl - wbPLO + salicylhydroxamic acid + SCN + I
2e9e – gPLO + nitrate + carbonate + SCN + CN
2efb – gPLO + phosphate + carbonate + SCN + CN
3qf1 - gPLO + piperazine + SCN + I
4ljj - gPLO + acrylonitrile + SCN + I
4msf, 4oek - gPLO + phenol derivative+ SCN + I
2eha – gPLO + formate + carbonate + SCN
3r55, 4n7a - gPLO + pyrazine derivative + SCN + I
3sxv - gPLO + amitrole + SCN + I
3r5q - sPLO +tetrahydrofuran + SCN + I
Proteopedia Page Contributors and Editors (what is this?)
Joel L. Sussman, Michal Harel, Alexander Berchansky, Jaime Prilusky
