Lignin peroxidase
From Proteopedia
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{{STRUCTURE_3q3u| PDB=3q3u | SIZE=400| SCENE= |right|CAPTION=Lignin peroxidase containing heme complex with MPD, Ca+2 (large green), Na+ (purple) and Cl- (small green) ions [[3q3u]] }} | {{STRUCTURE_3q3u| PDB=3q3u | SIZE=400| SCENE= |right|CAPTION=Lignin peroxidase containing heme complex with MPD, Ca+2 (large green), Na+ (purple) and Cl- (small green) ions [[3q3u]] }} | ||
| - | + | == Function == | |
| - | + | '''Lignin peroxidase''' (Lip) catalyzes the biodegradation of lignin using hydrogen peroxide. Lignin comprises 20-30% of woody plants cell wall. It is made of branched and heterogenous structure of phenylpropanoid units. It is highly resistant to biodegradation and only higher fungi are capable of degrading it. Veratryl alcohol is the cofactor in this reaction<ref>PMID:9790672</ref>. | |
| - | + | ||
| - | + | == Relevance == | |
| - | + | Lip is used as a skin-lightening active agent. | |
| - | '''Lignin peroxidase''' (Lip) catalyzes the biodegradation of lignin using hydrogen peroxide. Lignin comprises 20-30% of woody plants cell wall. It is made of branched and heterogenous structure of phenylpropanoid units. It is highly resistant to biodegradation and only higher fungi are capable of degrading it. Veratryl alcohol is the cofactor in this reaction. Lip is used as a skin-lightening active agent. | + | |
==3D structures of lignin peroxidase== | ==3D structures of lignin peroxidase== | ||
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[[3q3u]] – Lip – ''Trametes cervina'' | [[3q3u]] – Lip – ''Trametes cervina'' | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:41, 13 April 2016
Contents |
Function
Lignin peroxidase (Lip) catalyzes the biodegradation of lignin using hydrogen peroxide. Lignin comprises 20-30% of woody plants cell wall. It is made of branched and heterogenous structure of phenylpropanoid units. It is highly resistant to biodegradation and only higher fungi are capable of degrading it. Veratryl alcohol is the cofactor in this reaction[1].
Relevance
Lip is used as a skin-lightening active agent.
3D structures of lignin peroxidase
1lga, 1llp, 1qpa, 1b80, 1b82 – PcLip – Phanerochaete chrysosporium
1b85 – PcLip (mutant)
3q3u – Lip – Trametes cervina
References
- ↑ Doyle WA, Blodig W, Veitch NC, Piontek K, Smith AT. Two substrate interaction sites in lignin peroxidase revealed by site-directed mutagenesis. Biochemistry. 1998 Oct 27;37(43):15097-105. PMID:9790672 doi:http://dx.doi.org/10.1021/bi981633h
