This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Grb10 SH2 Domain
From Proteopedia
(Difference between revisions)
(Scene addition) |
|||
| Line 3: | Line 3: | ||
==Introduction== | ==Introduction== | ||
| - | Grb10 is a member of a family of adapter proteins that interacts with tyrosine kinases. <ref name=Guan>PMID: 12551896 </ref> | + | Grb10 is a member of a family of adapter proteins (Grb7 and Grb14) that interacts with tyrosine kinases. <ref name=Guan>PMID: 12551896 </ref> |
| + | ==Dimerization of the Grb10 SH2 Domain== | ||
| + | |||
| + | The crystal structure of Grb10 SH2 domain was an important step to understand how this protein interacts with IGF1 receptors and although the SH2 domain functions as an independent segment, it forms a dimer in physiological environments. <scene name='Grb10_SH2_Domain/Dimer_interface/1'>Dimer Interface</scene> | ||
</StructureSection> | </StructureSection> | ||
| + | |||
Revision as of 23:39, 6 November 2012
| |||||||||||
|
WOOOOOOOO
References
- ↑ Stein EG, Ghirlando R, Hubbard SR. Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity. J Biol Chem. 2003 Apr 11;278(15):13257-64. Epub 2003 Jan 27. PMID:12551896 doi:http://dx.doi.org/10.1074/jbc.M212026200
