Nuclear receptor coactivator
From Proteopedia
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{{STRUCTURE_1oj5| PDB=1oj5 | SIZE=400| SCENE= |right|CAPTION=Mouse nuclear receptor activator (grey) complex with STAT6 transactivator domain LXXLL peptide (green) and I-1 ions, [[1oj5]] }} | {{STRUCTURE_1oj5| PDB=1oj5 | SIZE=400| SCENE= |right|CAPTION=Mouse nuclear receptor activator (grey) complex with STAT6 transactivator domain LXXLL peptide (green) and I-1 ions, [[1oj5]] }} | ||
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| - | + | '''Nuclear receptor coactivator''' (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors<ref>PMID:9121485</ref>.<br /> | |
| - | + | *'''NCOA1''' shows histone acetyltransferase activity and is required for steroid hormone response.<br /> | |
| - | + | *'''NCOA2''' is a DNA transcription coactivator with glucocorticoid receptor.<br /> | |
| - | + | *'''NCOA3''' shows histone acetyltransferase activity. | |
| - | '''Nuclear receptor coactivator''' (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA | + | |
==3D structures of nuclear receptor coactivator== | ==3D structures of nuclear receptor coactivator== | ||
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[[1oj5]] – NCOA1A Pas-B domain + signal transducer and activator of transcription peptide - mouse | [[1oj5]] – NCOA1A Pas-B domain + signal transducer and activator of transcription peptide - mouse | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:19, 16 May 2016
Nuclear receptor coactivator (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors[1].
- NCOA1 shows histone acetyltransferase activity and is required for steroid hormone response.
- NCOA2 is a DNA transcription coactivator with glucocorticoid receptor.
- NCOA3 shows histone acetyltransferase activity.
3D structures of nuclear receptor coactivator
1v95 – hNCOA5 – human - NMR
1kbh – hNCOA + CREB-binding protein - NMR
2c52 – hNCOA1 residues 920-970 + CREB-binding protein - NMR
1oj5 – NCOA1A Pas-B domain + signal transducer and activator of transcription peptide - mouse
References
- ↑ Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L. Nuclear receptor coactivators and corepressors. Mol Endocrinol. 1996 Oct;10(10):1167-77. PMID:9121485 doi:http://dx.doi.org/10.1210/mend.10.10.9121485
