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Nuclear receptor coactivator

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{{STRUCTURE_1oj5| PDB=1oj5 | SIZE=400| SCENE= |right|CAPTION=Mouse nuclear receptor activator (grey) complex with STAT6 transactivator domain LXXLL peptide (green) and I-1 ions, [[1oj5]] }}
{{STRUCTURE_1oj5| PDB=1oj5 | SIZE=400| SCENE= |right|CAPTION=Mouse nuclear receptor activator (grey) complex with STAT6 transactivator domain LXXLL peptide (green) and I-1 ions, [[1oj5]] }}
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'''Nuclear receptor coactivator''' (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors<ref>PMID:9121485</ref>.<br />
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*'''NCOA1''' shows histone acetyltransferase activity and is required for steroid hormone response.<br />
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*'''NCOA2''' is a DNA transcription coactivator with glucocorticoid receptor.<br />
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*'''NCOA3''' shows histone acetyltransferase activity.
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'''Nuclear receptor coactivator''' (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA are involved in coactivation with transcription factors. NCOA1 shows histone acetyltransferase activity and is required for steroid hormone response. NCOA2 is a DNA transcription coactivator with glucocorticoid receptor. NCOA3 shows histone acetyltransferase activity.
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==3D structures of nuclear receptor coactivator==
==3D structures of nuclear receptor coactivator==
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[[1oj5]] – NCOA1A Pas-B domain + signal transducer and activator of transcription peptide - mouse
[[1oj5]] – NCOA1A Pas-B domain + signal transducer and activator of transcription peptide - mouse
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:19, 16 May 2016

Template:STRUCTURE 1oj5

Nuclear receptor coactivator (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors[1].

  • NCOA1 shows histone acetyltransferase activity and is required for steroid hormone response.
  • NCOA2 is a DNA transcription coactivator with glucocorticoid receptor.
  • NCOA3 shows histone acetyltransferase activity.

3D structures of nuclear receptor coactivator

1v95 – hNCOA5 – human - NMR
1kbh – hNCOA + CREB-binding protein - NMR
2c52 – hNCOA1 residues 920-970 + CREB-binding protein - NMR
1oj5 – NCOA1A Pas-B domain + signal transducer and activator of transcription peptide - mouse

References

  1. ↑ Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L. Nuclear receptor coactivators and corepressors. Mol Endocrinol. 1996 Oct;10(10):1167-77. PMID:9121485 doi:http://dx.doi.org/10.1210/mend.10.10.9121485

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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