1psd
From Proteopedia
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| - | [[Image:1psd.gif|left|200px]] | + | [[Image:1psd.gif|left|200px]] |
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| - | '''THE ALLOSTERIC LIGAND SITE IN THE VMAX-TYPE COOPERATIVE ENZYME PHOSPHOGLYCERATE DEHYDROGENASE''' | + | {{Structure |
| + | |PDB= 1psd |SIZE=350|CAPTION= <scene name='initialview01'>1psd</scene>, resolution 2.75Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene> and <scene name='pdbligand=SER:SERINE'>SER</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Phosphoglycerate_dehydrogenase Phosphoglycerate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.95 1.1.1.95] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''THE ALLOSTERIC LIGAND SITE IN THE VMAX-TYPE COOPERATIVE ENZYME PHOSPHOGLYCERATE DEHYDROGENASE''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1PSD is a [ | + | 1PSD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k12 Escherichia coli k12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSD OCA]. |
==Reference== | ==Reference== | ||
| - | The allosteric ligand site in the Vmax-type cooperative enzyme phosphoglycerate dehydrogenase., Schuller DJ, Grant GA, Banaszak LJ, Nat Struct Biol. 1995 Jan;2(1):69-76. PMID:[http:// | + | The allosteric ligand site in the Vmax-type cooperative enzyme phosphoglycerate dehydrogenase., Schuller DJ, Grant GA, Banaszak LJ, Nat Struct Biol. 1995 Jan;2(1):69-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7719856 7719856] |
[[Category: Escherichia coli k12]] | [[Category: Escherichia coli k12]] | ||
[[Category: Phosphoglycerate dehydrogenase]] | [[Category: Phosphoglycerate dehydrogenase]] | ||
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[[Category: oxidoreductase (nad(a))]] | [[Category: oxidoreductase (nad(a))]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:28:24 2008'' |
Revision as of 11:28, 20 March 2008
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| , resolution 2.75Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | and | ||||||
| Activity: | Phosphoglycerate dehydrogenase, with EC number 1.1.1.95 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE ALLOSTERIC LIGAND SITE IN THE VMAX-TYPE COOPERATIVE ENZYME PHOSPHOGLYCERATE DEHYDROGENASE
Overview
The crystal structure of the phosphoglycerate dehydrogenase from Escherichia coli is unique among dehydrogenases. It consists of three clearly separate domains connected by flexible hinges. The tetramer has approximate 222 symmetry with the principal contacts between the subunits forming between either the nucleotide binding domains or the regulatory domains. Two slightly different subunit conformations are present which vary only in the orientations of the domains. There is a hinge-like arrangement near the active site cleft and the serine effector site is provided by the regulatory domain of each of two subunits. Interdomain flexibility may play a key role in both catalysis and allosteric inhibition.
About this Structure
1PSD is a Single protein structure of sequence from Escherichia coli k12. Full crystallographic information is available from OCA.
Reference
The allosteric ligand site in the Vmax-type cooperative enzyme phosphoglycerate dehydrogenase., Schuller DJ, Grant GA, Banaszak LJ, Nat Struct Biol. 1995 Jan;2(1):69-76. PMID:7719856
Page seeded by OCA on Thu Mar 20 13:28:24 2008
