4a6d
From Proteopedia
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{{STRUCTURE_4a6d| PDB=4a6d | SCENE= }} | {{STRUCTURE_4a6d| PDB=4a6d | SCENE= }} | ||
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===Crystal structure of human N-acetylserotonin methyltransferase (ASMT) in complex with SAM=== | ===Crystal structure of human N-acetylserotonin methyltransferase (ASMT) in complex with SAM=== | ||
| + | {{ABSTRACT_PUBMED_22775292}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/ASMT_HUMAN ASMT_HUMAN]] Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.<ref>PMID:22775292</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[4a6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A6D OCA]. | [[4a6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A6D OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:022775292</ref><references group="xtra"/><references/> | ||
[[Category: Acetylserotonin O-methyltransferase]] | [[Category: Acetylserotonin O-methyltransferase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 05:10, 28 August 2013
Contents |
Crystal structure of human N-acetylserotonin methyltransferase (ASMT) in complex with SAM
Template:ABSTRACT PUBMED 22775292
Function
[ASMT_HUMAN] Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.[1]
About this Structure
4a6d is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Botros HG, Legrand P, Pagan C, Bondet V, Weber P, Ben-Abdallah M, Lemiere N, Huguet G, Bellalou J, Maronde E, Beguin P, Haouz A, Shepard W, Bourgeron T. Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway. J Pineal Res. 2012 Jun 12. doi: 10.1111/j.1600-079X.2012.01020.x. PMID:22775292 doi:10.1111/j.1600-079X.2012.01020.x
- ↑ Botros HG, Legrand P, Pagan C, Bondet V, Weber P, Ben-Abdallah M, Lemiere N, Huguet G, Bellalou J, Maronde E, Beguin P, Haouz A, Shepard W, Bourgeron T. Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway. J Pineal Res. 2012 Jun 12. doi: 10.1111/j.1600-079X.2012.01020.x. PMID:22775292 doi:10.1111/j.1600-079X.2012.01020.x
