1es6
From Proteopedia
(Difference between revisions)
m (Protected "1es6" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | [[ | + | ==CRYSTAL STRUCTURE OF THE MATRIX PROTEIN OF EBOLA VIRUS== |
| + | <StructureSection load='1es6' size='340' side='right' caption='[[1es6]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1es6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebola_virus_sp. Ebola virus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ES6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ES6 FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1es6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1es6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1es6 RCSB], [http://www.ebi.ac.uk/pdbsum/1es6 PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Ebola virus maturation occurs at the plasma membrane of infected cells and involves the clustering of the viral matrix protein VP40 at the assembly site as well as its interaction with the lipid bilayer. Here we report the X-ray crystal structure of VP40 from Ebola virus at 2.0 A resolution. The crystal structure reveals that Ebola virus VP40 is topologically distinct from all other known viral matrix proteins, consisting of two domains with unique folds, connected by a flexible linker. The C-terminal domain, which is absolutely required for membrane binding, contains large hydrophobic patches that may be involved in the interaction with lipid bilayers. Likewise, a highly basic region is shared between the two domains. The crystal structure reveals how the molecule may be able to switch from a monomeric conformation to a hexameric form, as observed in vitro. Its implications for the assembly process are discussed. | ||
| - | + | Crystal structure of the matrix protein VP40 from Ebola virus.,Dessen A, Volchkov V, Dolnik O, Klenk HD, Weissenhorn W EMBO J. 2000 Aug 15;19(16):4228-36. PMID:10944105<ref>PMID:10944105</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | == | + | |
| - | < | + | |
[[Category: Ebola virus sp.]] | [[Category: Ebola virus sp.]] | ||
[[Category: Dessen, A.]] | [[Category: Dessen, A.]] | ||
Revision as of 11:19, 24 September 2014
CRYSTAL STRUCTURE OF THE MATRIX PROTEIN OF EBOLA VIRUS
| |||||||||||
