Obscurin
From Proteopedia
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| - | {{ | + | {{STRUCTURE_2e7b| PDB=2e7b | SIZE=400| SCENE= |right|CAPTION=Obscurin N terminal complex with titin M10 domain, [[2e7b]] }} |
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'''Obscurin''' (Obs) is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains. | '''Obscurin''' (Obs) is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains. | ||
Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril. For more details see [[Group:MUZIC:Obscurin]]. | Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril. For more details see [[Group:MUZIC:Obscurin]]. | ||
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==3D structures of obscurin== | ==3D structures of obscurin== | ||
| - | [[3knb]], [[2wp3]], [[2wwm]] – hObs N terminal residues 1-105 + titin M10 domain – human<br /> | ||
| - | [[2wwk]] – hObs N terminal residues 1-105 (mutant) + titin M10 domain<br /> | ||
[[2e7b]] - hObs Ig domain residues 8-97 – NMR<BR /> | [[2e7b]] - hObs Ig domain residues 8-97 – NMR<BR /> | ||
[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR /> | [[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR /> | ||
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[[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR /> | [[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR /> | ||
[[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR /> | [[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR /> | ||
| + | [[3knb]], [[2wp3]], [[2wwm]] – hObs N terminal residues 1-105 + titin M10 domain – human<br /> | ||
| + | [[2wwk]] – hObs N terminal residues 1-105 (mutant) + titin M10 domain<br /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:31, 11 November 2012
Obscurin (Obs) is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains. Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril. For more details see Group:MUZIC:Obscurin.
3D structures of obscurin
2e7b - hObs Ig domain residues 8-97 – NMR
2eny - hObs Ig domain residues 2735-2825 – NMR
2edf - hObs Ig domain residues 2826-2915 – NMR
2cr6 - hObs Ig domain residues 2998-3100 – NMR
2yz8 - hObs Ig domain residues 3184-3273
2edr - hObs Ig domain residues 3361-3449 – NMR
2edt - hObs Ig domain residues 3449-3537 – NMR
2edw - hObs I-set domain residues 3537-3630 – NMR
2edh – hObs PDZ domain residues 3614-3713 – NMR
2edq - hObs Ig domain residues 3713-3806 – NMR
2edl - hObs Ig domain residues 3801-3897 – NMR
1v1c - hObs SH3 domain residues 5601-5668 – NMR
Obscurin-like protein 1
2e6q - hObsL Ig domain residues 615-713 – NMR
2e6p - hObsL Ig domain residues 714-804 – NMR
3knb, 2wp3, 2wwm – hObs N terminal residues 1-105 + titin M10 domain – human
2wwk – hObs N terminal residues 1-105 (mutant) + titin M10 domain
