1pzu

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[[Image:1pzu.gif|left|200px]]<br /><applet load="1pzu" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1pzu.gif|left|200px]]
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caption="1pzu, resolution 3.10&Aring;" />
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'''An asymmetric NFAT1-RHR homodimer on a pseudo-palindromic, Kappa-B site'''<br />
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{{Structure
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|PDB= 1pzu |SIZE=350|CAPTION= <scene name='initialview01'>1pzu</scene>, resolution 3.10&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= NFAT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''An asymmetric NFAT1-RHR homodimer on a pseudo-palindromic, Kappa-B site'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1PZU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZU OCA].
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1PZU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZU OCA].
==Reference==
==Reference==
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An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site., Jin L, Sliz P, Chen L, Macian F, Rao A, Hogan PG, Harrison SC, Nat Struct Biol. 2003 Oct;10(10):807-11. Epub 2003 Aug 31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12949491 12949491]
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An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site., Jin L, Sliz P, Chen L, Macian F, Rao A, Hogan PG, Harrison SC, Nat Struct Biol. 2003 Oct;10(10):807-11. Epub 2003 Aug 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12949491 12949491]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transcription factor]]
[[Category: transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:34:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:31:09 2008''

Revision as of 11:31, 20 March 2008

Image:1pzu.gif


PDB ID 1pzu

Drag the structure with the mouse to rotate
, resolution 3.10Å
Gene: NFAT1 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



An asymmetric NFAT1-RHR homodimer on a pseudo-palindromic, Kappa-B site


Overview

The crystal structure of the NFAT1 Rel homology region (RHR) bound to a pseudo-palindromic DNA site reveals an asymmetric dimer interaction between the RHR-C domains, unrelated to the contact seen in Rel dimers such as NF kappa B. Binding studies with a form of the NFAT1 RHR defective in the dimer contact show loss of cooperativity and demonstrate that the same interaction is present in solution. The structure we have determined may correspond to a functional NFAT binding mode at palindromic sites of genes induced during the anergic response to weak TCR signaling.

About this Structure

1PZU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site., Jin L, Sliz P, Chen L, Macian F, Rao A, Hogan PG, Harrison SC, Nat Struct Biol. 2003 Oct;10(10):807-11. Epub 2003 Aug 31. PMID:12949491

Page seeded by OCA on Thu Mar 20 13:31:09 2008

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