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4hvx

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4hvx| PDB=4hvx | SCENE= }}
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===tRNA-guanine transglycosylase Y106F, C158V mutant in complex with queuine===
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{{ABSTRACT_PUBMED_23704982}}
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The entry 4hvx is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]
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Authors: Biela, I., Tidten-Luksch, N., Heine, A., Reuter, K., Klebe, G.
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==About this Structure==
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[[4hvx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_zm4_=_atcc_31821 Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HVX OCA].
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Description: tRNA-guanine transglycosylase Y106F, C158V mutant in complex with queuine
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==See Also==
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*[[TRNA-guanine transglycosylase|TRNA-guanine transglycosylase]]
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==Reference==
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<ref group="xtra">PMID:023704982</ref><references group="xtra"/><references/>
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[[Category: Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]]
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[[Category: Biela, I.]]
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[[Category: Heine, A.]]
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[[Category: Klebe, G.]]
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[[Category: Reuter, K.]]
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[[Category: Tidten-Luksch, N.]]
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[[Category: Bacterial tgt]]
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[[Category: Guanine exchange enzyme]]
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[[Category: Queuine]]
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[[Category: Substrate specificity]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 04:30, 18 July 2013

Template:STRUCTURE 4hvx

Contents

tRNA-guanine transglycosylase Y106F, C158V mutant in complex with queuine

Template:ABSTRACT PUBMED 23704982

Function

[TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]

About this Structure

4hvx is a 1 chain structure with sequence from Zymomonas mobilis subsp. mobilis zm4 = atcc 31821. Full crystallographic information is available from OCA.

See Also

Reference

  • Biela I, Tidten-Luksch N, Immekus F, Glinca S, Nguyen TX, Gerber HD, Heine A, Klebe G, Reuter K. Investigation of specificity determinants in bacterial tRNA-guanine transglycosylase reveals queuine, the substrate of its eucaryotic counterpart, as inhibitor. PLoS One. 2013 May 21;8(5):e64240. doi: 10.1371/journal.pone.0064240. Print 2013. PMID:23704982 doi:10.1371/journal.pone.0064240

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