1q3a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1q3a.jpg|left|200px]]<br /><applet load="1q3a" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1q3a.jpg|left|200px]]
-
caption="1q3a, resolution 2.10&Aring;" />
+
 
-
'''Crystal structure of the catalytic domain of human matrix metalloproteinase 10'''<br />
+
{{Structure
 +
|PDB= 1q3a |SIZE=350|CAPTION= <scene name='initialview01'>1q3a</scene>, resolution 2.10&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID'>NGH</scene>
 +
|ACTIVITY= [http://en.wikipedia.org/wiki/Stromelysin_2 Stromelysin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.22 3.4.24.22]
 +
|GENE= MMP10 OR STMY2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
 +
}}
 +
 
 +
'''Crystal structure of the catalytic domain of human matrix metalloproteinase 10'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
1Q3A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=NGH:'>NGH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Stromelysin_2 Stromelysin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.22 3.4.24.22] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3A OCA].
+
1Q3A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3A OCA].
==Reference==
==Reference==
-
Crystal structure of the catalytic domain of human matrix metalloproteinase 10., Bertini I, Calderone V, Fragai M, Luchinat C, Mangani S, Terni B, J Mol Biol. 2004 Feb 20;336(3):707-16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15095982 15095982]
+
Crystal structure of the catalytic domain of human matrix metalloproteinase 10., Bertini I, Calderone V, Fragai M, Luchinat C, Mangani S, Terni B, J Mol Biol. 2004 Feb 20;336(3):707-16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15095982 15095982]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 24: Line 33:
[[Category: ZN]]
[[Category: ZN]]
[[Category: hydroxamic acid]]
[[Category: hydroxamic acid]]
-
[[Category: inhibitors]]
+
[[Category: inhibitor]]
[[Category: metalloproteinase]]
[[Category: metalloproteinase]]
[[Category: mmp-10]]
[[Category: mmp-10]]
Line 30: Line 39:
[[Category: stromelysin-2]]
[[Category: stromelysin-2]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:35:26 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:32:26 2008''

Revision as of 11:32, 20 March 2008

Image:1q3a.jpg


PDB ID 1q3a

Drag the structure with the mouse to rotate
, resolution 2.10Å
Ligands: , and
Gene: MMP10 OR STMY2 (Homo sapiens)
Activity: Stromelysin 2, with EC number 3.4.24.22
Coordinates: save as pdb, mmCIF, xml



Crystal structure of the catalytic domain of human matrix metalloproteinase 10


Overview

The catalytic domain of matrix metalloproteinase-10 (MMP-10) has been expressed in Escherichia coli and its crystal structure solved at 2.1 A resolution. The availability of this structure allowed us to critically examine the small differences existing between the catalytic domains of MMP-3 and MMP-10, which show the highest sequence identity among all MMPs. Furthermore, the binding mode of N-isobutyl-N-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid (NNGH), which is one of the most known commercial inhibitors of MMPs, is described for the first time.

About this Structure

1Q3A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic domain of human matrix metalloproteinase 10., Bertini I, Calderone V, Fragai M, Luchinat C, Mangani S, Terni B, J Mol Biol. 2004 Feb 20;336(3):707-16. PMID:15095982

Page seeded by OCA on Thu Mar 20 13:32:26 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1q3a"
Personal tools