4f5d

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[[Image:4f5d.png|left|200px]]
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==ERIS/STING in complex with ligand==
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<StructureSection load='4f5d' size='340' side='right' caption='[[4f5d]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4f5d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F5D FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3AS,5S,7AR,9R,10R,10AS,12S,14AR)-3,5,10,12-TETRAHYDROXY-5,12-DIOXIDOOCTAHYDRO-2H,7H-DIFURO[3,2-D 3,2-J][1,3,7,9,2,8]TETRAOXADIPHOSPHACYCLODODECINE-2,9-DIYL]BIS(2-AMINO-1,9-DIHYDRO-6H-PURIN-6-ONE)'>C2E</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4f5e|4f5e]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TMEM173, ERIS, MITA, STING ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f5d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f5d RCSB], [http://www.ebi.ac.uk/pdbsum/4f5d PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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STING (stimulator of interferon genes) is an essential signaling adaptor that mediates cytokine production in response to microbial invasion by directly sensing bacterial secondary messengers such as the cyclic dinucleotide bis-(3'-5')-cyclic dimeric GMP (c-di-GMP). STING's structure and its binding mechanism to cyclic dinucleotides were unknown. We report here the crystal structures of the STING cytoplasmic domain and its complex with c-di-GMP, thus providing the structural basis for understanding STING function.
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{{STRUCTURE_4f5d| PDB=4f5d | SCENE= }}
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The structural basis for the sensing and binding of cyclic di-GMP by STING.,Huang YH, Liu XY, Du XX, Jiang ZF, Su XD Nat Struct Mol Biol. 2012 Jun 24;19(7):728-30. doi: 10.1038/nsmb.2333. PMID:22728659<ref>PMID:22728659</ref>
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===ERIS/STING in complex with ligand===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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==About this Structure==
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*[[Stimulator of interferon genes|Stimulator of interferon genes]]
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[[4f5d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F5D OCA].
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Huang, Y H.]]
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[[Category: Huang, Y H]]
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[[Category: Liu, X Y.]]
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[[Category: Liu, X Y]]
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[[Category: Su, X D.]]
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[[Category: Su, X D]]
[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Receptor]]
[[Category: Receptor]]

Revision as of 16:35, 9 December 2014

ERIS/STING in complex with ligand

4f5d, resolution 3.00Å

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