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1q56

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[[Image:1q56.jpg|left|200px]]<br /><applet load="1q56" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1q56.jpg|left|200px]]
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caption="1q56" />
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'''NMR structure of the B0 isoform of the agrin G3 domain in its Ca2+ bound state'''<br />
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{{Structure
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|PDB= 1q56 |SIZE=350|CAPTION= <scene name='initialview01'>1q56</scene>
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= AGRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])
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}}
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'''NMR structure of the B0 isoform of the agrin G3 domain in its Ca2+ bound state'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1Q56 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q56 OCA].
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1Q56 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q56 OCA].
==Reference==
==Reference==
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Modulation of agrin function by alternative splicing and Ca2+ binding., Stetefeld J, Alexandrescu AT, Maciejewski MW, Jenny M, Rathgeb-Szabo K, Schulthess T, Landwehr R, Frank S, Ruegg MA, Kammerer RA, Structure. 2004 Mar;12(3):503-15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15016366 15016366]
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Modulation of agrin function by alternative splicing and Ca2+ binding., Stetefeld J, Alexandrescu AT, Maciejewski MW, Jenny M, Rathgeb-Szabo K, Schulthess T, Landwehr R, Frank S, Ruegg MA, Kammerer RA, Structure. 2004 Mar;12(3):503-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15016366 15016366]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: nmj synapse]]
[[Category: nmj synapse]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:35:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:33:05 2008''

Revision as of 11:33, 20 March 2008

Image:1q56.jpg


PDB ID 1q56

Drag the structure with the mouse to rotate
Gene: AGRN (Gallus gallus)
Coordinates: save as pdb, mmCIF, xml



NMR structure of the B0 isoform of the agrin G3 domain in its Ca2+ bound state


Overview

The aggregation of acetylcholine receptors on postsynaptic membranes is a key step in neuromuscular junction development. This process depends on alternatively spliced forms of the proteoglycan agrin with "B-inserts" of 8, 11, or 19 residues in the protein's globular C-terminal domain, G3. Structures of the neural B8 and B11 forms of agrin-G3 were determined by X-ray crystallography. The structure of G3-B0, which lacks inserts, was determined by NMR. The agrin-G3 domain adopts a beta jellyroll fold. The B insert site is flanked by four loops on one edge of the beta sandwich. The loops form a surface that corresponds to a versatile interaction interface in the family of structurally related LNS proteins. NMR and X-ray data indicate that this interaction interface is flexible in agrin-G3 and that flexibility is reduced by Ca(2+) binding. The plasticity of the interaction interface could enable different splice forms of agrin to select between multiple binding partners.

About this Structure

1Q56 is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Modulation of agrin function by alternative splicing and Ca2+ binding., Stetefeld J, Alexandrescu AT, Maciejewski MW, Jenny M, Rathgeb-Szabo K, Schulthess T, Landwehr R, Frank S, Ruegg MA, Kammerer RA, Structure. 2004 Mar;12(3):503-15. PMID:15016366

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